Allergy Asthma Immunol Res:一项比较老年和年轻成人过敏性鼻炎临床结果的前瞻性研究

2021-02-06 AlexYang MedSci原创

虽然过敏性鼻炎(AR)年轻患者已经成功地进行了药物治疗,但目前还没有老年AR患者治疗效果的确切数据。

虽然过敏性鼻炎(AR)年轻患者已经成功地进行了药物治疗,但目前还没有老年AR患者治疗效果的确切数据

最近,有研究人员对51名老年AR患者(年龄在65岁以上)和101名年轻AR患者(年龄在19~40岁)进行了前瞻性研究,比较了2组患者的临床效果,并评估抑郁情绪对老年AR患者治疗效果的影响。研究人员根据过敏性鼻炎及其对哮喘的影响(ARIA)指南,评估了治疗4周后总症状评分(TSS)、鼻炎特异性生活质量问卷(RQLQ)结果、鼻炎控制评估测试(RCAT)结果和视觉模拟量表(VAS)评分的变化,并采用老年抑郁量表评估了抑郁情绪的严重程度。结果表明,经过4周的治疗,年轻的AR患者与老年患者相比,临床评分有更大的改善;老年患者与年轻患者较基线的最小二乘平均变化差异为:TSS为1.71(P=0.004),RQLQ为10.84(P<0.001),RCAT为0.80(P=0.275)和VAS评分为8.60(P=0.061)。多重逻辑回归分析显示,抑郁情绪的严重程度与严重的慢性上呼吸道疾病独立相关(调整后的让步比,1.385;P=0.004)。

最后,研究人员指出,与年轻AR患者相比,老年AR患者对标准治疗的响应较差,抑郁情绪与老年AR患者AR的风险增加密切相关

原始出处:

Seong Dae Woo , So Hee Lee , Young Min Ye et al. A Prospective Study to Compare Clinical Outcomes of Allergic Rhinitis Between Older and Younger Adults: A Potential Effect of Depression in Older Patients. Allergy Asthma Immunol Res. 2021

 

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    2021-12-22 skhzy
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    2021-02-08 膀胱癌

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Nat Med:食道TSLP 和嗜碱细胞可能是食物过敏性疾病的重要机制

食物是通常由碳水化合物、脂肪、蛋白质或水构成,能够借由进食或是饮用为人类或者生物提供营养或愉悦的物质。但是对于一些人来说,它们可能是有害的。 不恰当的免疫反应导致了人类对一些食物的过敏性炎症,这已经成为了一个重要的公众健康问题。在过去的十年里,食物过敏的患病率增加了近 20%。 嗜酸细胞性食管炎(Eosinophilic Esophagitis, EoE)是一类儿童和成人的食物过敏相关疾病,它