Anticancer Res:缺氧环境可改变黑色素瘤细胞外泌体miRNA的表达谱

2017-12-03 MedSci MedSci原创

黑素瘤来源的外泌体中运输的微小RNAs(miRNAs)作为支持肿瘤存活和进展的细胞间信使发挥功能。缺氧增加黑色素瘤的表型可塑性、耐药性和转移。 研究人员通过微阵列分析和逆转录-聚合酶链反应(RT-PCR)来确定在缺氧和常氧条件下生长的黑色素瘤细胞所分泌的外来体中的miRNA表达谱,以分析外泌体运输的miRNA对癌症相关通路的潜在影响及转录程序。 结果显示,尽管所使用的四种细胞系存在表型差异,但其外

黑素瘤来源的外泌体中运输的微小RNAs(miRNAs)作为支持肿瘤存活和进展的细胞间信使发挥功能。缺氧增加黑色素瘤的表型可塑性、耐药性和转移。

研究人员通过微阵列分析和逆转录-聚合酶链反应(RT-PCR)来确定在缺氧和常氧条件下生长的黑色素瘤细胞所分泌的外来体中的miRNA表达谱,以分析外泌体运输的miRNA对癌症相关通路的潜在影响及转录程序。

结果显示,尽管所使用的四种细胞系存在表型差异,但其外泌体miRNAs的表达谱类似。常氧外泌体中三种miRNAs的表达水平较高,而缺氧条件下15种miRNAs的表达水平明显升高。通路分析指出了一些有助于癌细胞增殖、耐药性和肿瘤微环境改变的细胞过程,包括免疫抑制。

综上所述,该研究结果表明,黑色素瘤细胞分泌的外泌体miRNA表达谱可因氧浓度不同而发生改变,并反映不同生长条件下黑素瘤细胞的表型变化。

原始出处:

Wozniak M, Peczek L, Czernek L, Düchler M. Analysis of the miRNA Profiles of Melanoma Exosomes Derived Under Normoxic and Hypoxic Culture Conditions. Anticancer Res. 2017 Dec;37(12):6779-6789.

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    2018-05-23 sunylz
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    2018-01-20 smallant2002
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    2017-12-05 Homburg
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    2017-12-03 三生有幸9135

    学习一下谢谢分享

    0

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    2017-12-03 flysky120

    学习一下知识了谢谢

    0

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    2017-12-03 Jackie Li

    学习

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