JAHA:轻度升高的肺动脉压与肺动脉高压进展以及死亡率增加高风险相关

2021-03-23 MedSci原创 MedSci原创

该研究的结果表明,PAP轻度升高的个体与正常PAP的个体相比,发生PH和死亡的风险增加。

肺动脉高压(PH)是通过右心导管检查测得的平均肺动脉压(PAP)≥25 mmHg来进行诊断。但是,平均PAP正常范围的上限为20 mmHg。平均PAP正常范围的上限与诊断PH的阈值之间存在差距。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在探究PAP轻度升高(定义为20 mmHg<平均PAP<25 mmHg)是否比正常PAP的患者发生PH或死亡的风险增加。

研究人员回顾性分析了评估PAP轻度升高与PAP正常的受试者发展为PH和/或死亡风险的研究。每名参与者的平均PAP值是通过右心导管检查得到证实。

研究人员审查了1213项研究,其中8项研究符合研究人员的纳入标准。该分析的结果表明,PAP轻度升高的受试者发展为PH的可能性是PAP正常受试者的1.81至2.45倍。PAP轻度升高和正常PAP组之间的死亡率有统计学上的显著差异(风险比为2.48;95%CI为1.69-3.64)。研究人员还汇总了各组的生存概率以获得每组患者的汇总生存曲线,轻度升高的PAP受试者合并生存率在数值上低于正常PAP的受试者。

由此可见,该研究的结果表明,PAP轻度升高的个体与正常PAP的个体相比,发生PH和死亡的风险增加。

原始出处:

Lin Xue.et al.Mildly Elevated Pulmonary Arterial Pressure Is Associated With a High Risk of Progression to Pulmonary Hypertension and Increased Mortality: A Systematic Review and Meta‐Analysis.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.018374

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    2021-07-14 ms5000001266883663

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content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Mar 25 10:22:07 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460693, encodeId=46e514606938c, content=<a href='/topic/show?id=42a182045eb' target=_blank style='color:#2F92EE;'>#肺动脉压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82045, encryptionId=42a182045eb, topicName=肺动脉压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b1e6357266, createdName=hxzhang, createdTime=Thu Mar 25 10:22:07 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950536, encodeId=e60b950536c1, content=<a href='/topic/show?id=0bad820e112' target=_blank style='color:#2F92EE;'>#肺动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82071, encryptionId=0bad820e112, topicName=肺动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Mar 23 23:11:27 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050919, encodeId=a354105091963, content=肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Tue Mar 23 22:22:07 CST 2021, time=2021-03-23, status=1, ipAttribution=)]
  5. 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content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Mar 25 10:22:07 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460693, encodeId=46e514606938c, content=<a href='/topic/show?id=42a182045eb' target=_blank style='color:#2F92EE;'>#肺动脉压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82045, encryptionId=42a182045eb, topicName=肺动脉压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b1e6357266, createdName=hxzhang, createdTime=Thu Mar 25 10:22:07 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950536, encodeId=e60b950536c1, content=<a href='/topic/show?id=0bad820e112' target=_blank style='color:#2F92EE;'>#肺动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82071, encryptionId=0bad820e112, topicName=肺动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Mar 23 23:11:27 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050919, encodeId=a354105091963, content=肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Tue Mar 23 22:22:07 CST 2021, time=2021-03-23, status=1, ipAttribution=)]
    2021-03-26 ms7000001243216718

    👍

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1862154, encodeId=5b12186215467, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Wed May 19 20:22:07 CST 2021, time=2021-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986614, encodeId=173219866142e, content=<a href='/topic/show?id=c36433231aa' target=_blank style='color:#2F92EE;'>#动脉压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33231, encryptionId=c36433231aa, topicName=动脉压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, 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content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Mar 25 10:22:07 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460693, encodeId=46e514606938c, content=<a href='/topic/show?id=42a182045eb' target=_blank style='color:#2F92EE;'>#肺动脉压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82045, encryptionId=42a182045eb, topicName=肺动脉压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b1e6357266, createdName=hxzhang, createdTime=Thu Mar 25 10:22:07 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950536, encodeId=e60b950536c1, content=<a href='/topic/show?id=0bad820e112' target=_blank style='color:#2F92EE;'>#肺动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82071, encryptionId=0bad820e112, topicName=肺动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Mar 23 23:11:27 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050919, encodeId=a354105091963, content=肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Tue Mar 23 22:22:07 CST 2021, time=2021-03-23, status=1, ipAttribution=)]
    2021-03-26 1351e9d03fm

    很好👍

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1862154, encodeId=5b12186215467, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Wed May 19 20:22:07 CST 2021, time=2021-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1986614, encodeId=173219866142e, content=<a href='/topic/show?id=c36433231aa' target=_blank style='color:#2F92EE;'>#动脉压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33231, encryptionId=c36433231aa, topicName=动脉压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, 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createdTime=Thu Apr 22 21:22:07 CST 2021, time=2021-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951471, encodeId=4aba9514e134, content=👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba2a5473648, createdName=ms7000001243216718, createdTime=Fri Mar 26 21:31:19 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951367, encodeId=d06a95136e0d, content=很好👍, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=011b2041687, createdName=1351e9d03fm, createdTime=Fri Mar 26 12:17:56 CST 2021, time=2021-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268471, encodeId=347012684e160, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Mar 25 10:22:07 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460693, encodeId=46e514606938c, content=<a href='/topic/show?id=42a182045eb' target=_blank style='color:#2F92EE;'>#肺动脉压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82045, encryptionId=42a182045eb, topicName=肺动脉压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b1e6357266, createdName=hxzhang, createdTime=Thu Mar 25 10:22:07 CST 2021, time=2021-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950536, encodeId=e60b950536c1, content=<a href='/topic/show?id=0bad820e112' target=_blank style='color:#2F92EE;'>#肺动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82071, encryptionId=0bad820e112, topicName=肺动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Mar 23 23:11:27 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050919, encodeId=a354105091963, content=肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Tue Mar 23 22:22:07 CST 2021, time=2021-03-23, status=1, ipAttribution=)]
    2021-03-25 zhaohui6731
  8. 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  9. 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authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Tue Mar 23 22:22:07 CST 2021, time=2021-03-23, status=1, ipAttribution=)]
    2021-03-23 明天jing

    肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。

    0

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