BMC Gastroenterology:HIV感染是否会增加肝脏脂肪变的可能性

2019-05-13 不详 MedSci原创

肝脏脂肪变性在西方国家很普遍,但很少有研究评估在HIV感染情况下脂肪变性的频率和严重程度是否更高。因此,本项研究比较了HIV感染(HIV +)和未感染者之间肝脏脂肪变性的患病率和严重程度,并确定了两组中脂肪变性严重程度相关的因素。

背景
肝脏脂肪变性在西方国家很普遍,但很少有研究评估在HIV感染情况下脂肪变性的频率和严重程度是否更高。因此,本项研究比较了HIV感染(HIV +)和未感染者之间肝脏脂肪变性的患病率和严重程度,并确定了两组中脂肪变性严重程度相关的因素。

方法
研究人员在没有血管疾病的参与者中进行了一项横断面研究,通过非对比计算机断层扫描(CT)肝 - 脾(L / S)衰减比<1.0来定义肝脂肪变性。多变量线性回归用于:1)评估HIV感染与肝脂肪变性严重程度之间的关联(通过绝对肝衰减测量),2)通过HIV状态确定与脂肪变性严重程度相关的因素。

结果
在268名参与者中(中位年龄,55岁; 99%男性; 79%黑人; 23%肥胖; 64%HIV + [91%抗逆转录病毒治疗]),脂肪变性的总体患病率为7.8%,HIV +和未感染者之间相似(13 [7.6%] VS 8 [8.2%]; p  = 0.85)。与未感染的参与者相比,感染艾滋病毒的参与者(其中大多数接受了抗逆转录病毒治疗)的平均绝对肝脏衰减较高(平均差异,5.68 Hounsfield单位; p  <0.001),与较小的肝脏脂肪变性严重程度相关。调整协变量后,只有晚期肝纤维化与HIV +人(p  = 0.03)和未感染者(p  <0.001)的脂肪变性严重程度相关。

结论
本项研究结果表明肝脏脂肪变性患病率与艾滋病病毒感染状况没有差异。脂肪变性严重程度与晚期肝纤维化独立相关。

原始出处:

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    2019-10-17 许安
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    2019-05-17 一个字-牛

    学习了谢谢分享

    0

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