Diabetes Care:接种流感疫苗与糖尿病成人心血管死亡率降低相关

2020-07-10 MedSci原创 MedSci原创

在糖尿病患者中,接种流感疫苗可降低全因死亡,心血管死亡以及AMI或卒中死亡的风险。流感疫苗接种可以改善糖尿病患者的预后。

流感感染与动脉粥样血栓形成事件的风险增加有关,包括急性心肌梗塞(AMI)和卒中。对于糖尿病患者的流感疫苗接种与血管结局之间的关系知之甚少。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员使用了全国注册数据来确定2007-2016年期间9个流感季节中丹麦的糖尿病患者。糖尿病被定义为使用降糖药。年龄不在18–100岁之间或患有缺血性心脏病、心力衰竭、慢性阻塞性肺疾病、癌症或脑血管疾病的患者被排除在外。在每个流感季节之前评估患者的流感疫苗接种情况。研究人员考虑了所有原因导致的死亡、心血管原因导致的死亡以及AMI或卒中导致的死亡。对于每个季节,从12月1日至第二年4月1日对患者进行监测。

研究人员总共监测了241551名患者,平均四个季节(四分位间距二至八个季节),总共随访了425318人次每年。研究期间季节的疫苗覆盖率在24%到36%之间。在随访期间,共有8207名患者全因死亡(3.4%),4127名患者死于心血管疾病(1.7%),1439名患者死于AMI/卒中(0.6%)。调整混杂因素后,接种疫苗与降低全因死亡风险(风险比[HR]为0.83,P<0.001)、心血管死亡(HR为0.84,P<0.001)、AMI或卒中导致的死亡(HR为0.85,P=0.028),并降低了因糖尿病(糖尿病酮症酸中毒、低血糖或昏迷)而出现的急性并发症入院的风险(HR为0.89,P=0.006)。

在糖尿病患者中,接种流感疫苗可降低全因死亡,心血管死亡以及AMI或卒中死亡的风险。流感疫苗接种可以改善糖尿病患者的预后。

原始出处:

Daniel Modin.et al.Influenza Vaccination Is Associated With Reduced Cardiovascular Mortality in Adults With Diabetes: A Nationwide Cohort Study.Diabetes Care.2020.https://doi.org/10.2337/dc20-0229

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  1. 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encodeId=9fc71043213d0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jul 10 23:39:25 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802350, encodeId=8d1a80235056, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>这个人就跟我们去试试,当我们拿到数据以后,那些看似无关的信息,通过适当的分析都可能会判断出他们之间存在某种关联,这种关联有可能会指导临床实践。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:45:41 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802349, encodeId=4b698023499b, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>这个研究这个架子的价与我们平时忽视的一些点,你1秒的防护,与糖尿病的关联,虽然疫苗和潭利平之间可能是间接关系,但是对于临泉的指导价值依然很大的这个研究。事实上,如果进一步分析的老年人中接种流感疫苗可能会更大幅度的降低了糖尿病相关的死亡风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:45:07 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802348, encodeId=97df802348c0, content=<a href='/topic/show?id=76456533481' 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    2021-02-17 zhouqu_8
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target=_blank style='color:#2F92EE;'>#流感疫苗#</a>可能是因为接种了流感疫苗以后,降低了呼吸道并发症的发生,从而减少了糖尿病的并发症并发症的减少,其实带来死亡风险的降低。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65334, encryptionId=76456533481, topicName=流感疫苗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:44:15 CST 2020, time=2020-07-10, status=1, ipAttribution=)]
  4. 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encodeId=9fc71043213d0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jul 10 23:39:25 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802350, encodeId=8d1a80235056, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>这个人就跟我们去试试,当我们拿到数据以后,那些看似无关的信息,通过适当的分析都可能会判断出他们之间存在某种关联,这种关联有可能会指导临床实践。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, 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target=_blank style='color:#2F92EE;'>#流感疫苗#</a>可能是因为接种了流感疫苗以后,降低了呼吸道并发症的发生,从而减少了糖尿病的并发症并发症的减少,其实带来死亡风险的降低。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65334, encryptionId=76456533481, topicName=流感疫苗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:44:15 CST 2020, time=2020-07-10, status=1, ipAttribution=)]
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encodeId=9fc71043213d0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jul 10 23:39:25 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802350, encodeId=8d1a80235056, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>这个人就跟我们去试试,当我们拿到数据以后,那些看似无关的信息,通过适当的分析都可能会判断出他们之间存在某种关联,这种关联有可能会指导临床实践。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, 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target=_blank style='color:#2F92EE;'>#流感疫苗#</a>可能是因为接种了流感疫苗以后,降低了呼吸道并发症的发生,从而减少了糖尿病的并发症并发症的减少,其实带来死亡风险的降低。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65334, encryptionId=76456533481, topicName=流感疫苗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:44:15 CST 2020, time=2020-07-10, status=1, ipAttribution=)]
  6. 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encodeId=9fc71043213d0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jul 10 23:39:25 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802350, encodeId=8d1a80235056, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>这个人就跟我们去试试,当我们拿到数据以后,那些看似无关的信息,通过适当的分析都可能会判断出他们之间存在某种关联,这种关联有可能会指导临床实践。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:45:41 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802349, encodeId=4b698023499b, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>这个研究这个架子的价与我们平时忽视的一些点,你1秒的防护,与糖尿病的关联,虽然疫苗和潭利平之间可能是间接关系,但是对于临泉的指导价值依然很大的这个研究。事实上,如果进一步分析的老年人中接种流感疫苗可能会更大幅度的降低了糖尿病相关的死亡风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:45:07 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802348, encodeId=97df802348c0, content=<a href='/topic/show?id=76456533481' target=_blank style='color:#2F92EE;'>#流感疫苗#</a>可能是因为接种了流感疫苗以后,降低了呼吸道并发症的发生,从而减少了糖尿病的并发症并发症的减少,其实带来死亡风险的降低。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65334, encryptionId=76456533481, topicName=流感疫苗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:44:15 CST 2020, time=2020-07-10, status=1, ipAttribution=)]
    2020-07-10 misszhang

    谢谢MedSci提供最新的资讯

    0

  7. 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encodeId=9fc71043213d0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jul 10 23:39:25 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802350, encodeId=8d1a80235056, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>这个人就跟我们去试试,当我们拿到数据以后,那些看似无关的信息,通过适当的分析都可能会判断出他们之间存在某种关联,这种关联有可能会指导临床实践。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:45:41 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802349, encodeId=4b698023499b, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>这个研究这个架子的价与我们平时忽视的一些点,你1秒的防护,与糖尿病的关联,虽然疫苗和潭利平之间可能是间接关系,但是对于临泉的指导价值依然很大的这个研究。事实上,如果进一步分析的老年人中接种流感疫苗可能会更大幅度的降低了糖尿病相关的死亡风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:45:07 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802348, encodeId=97df802348c0, content=<a href='/topic/show?id=76456533481' target=_blank style='color:#2F92EE;'>#流感疫苗#</a>可能是因为接种了流感疫苗以后,降低了呼吸道并发症的发生,从而减少了糖尿病的并发症并发症的减少,其实带来死亡风险的降低。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65334, encryptionId=76456533481, topicName=流感疫苗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:44:15 CST 2020, time=2020-07-10, status=1, ipAttribution=)]
    2020-07-10 lovetcm

    #糖尿病#这个人就跟我们去试试,当我们拿到数据以后,那些看似无关的信息,通过适当的分析都可能会判断出他们之间存在某种关联,这种关联有可能会指导临床实践。

    0

  8. 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encodeId=9fc71043213d0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jul 10 23:39:25 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802350, encodeId=8d1a80235056, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>这个人就跟我们去试试,当我们拿到数据以后,那些看似无关的信息,通过适当的分析都可能会判断出他们之间存在某种关联,这种关联有可能会指导临床实践。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, 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target=_blank style='color:#2F92EE;'>#流感疫苗#</a>可能是因为接种了流感疫苗以后,降低了呼吸道并发症的发生,从而减少了糖尿病的并发症并发症的减少,其实带来死亡风险的降低。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65334, encryptionId=76456533481, topicName=流感疫苗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:44:15 CST 2020, time=2020-07-10, status=1, ipAttribution=)]
    2020-07-10 lovetcm

    #糖尿病#这个研究这个架子的价与我们平时忽视的一些点,你1秒的防护,与糖尿病的关联,虽然疫苗和潭利平之间可能是间接关系,但是对于临泉的指导价值依然很大的这个研究。事实上,如果进一步分析的老年人中接种流感疫苗可能会更大幅度的降低了糖尿病相关的死亡风险。

    0

  9. 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encodeId=9fc71043213d0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jul 10 23:39:25 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802350, encodeId=8d1a80235056, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>这个人就跟我们去试试,当我们拿到数据以后,那些看似无关的信息,通过适当的分析都可能会判断出他们之间存在某种关联,这种关联有可能会指导临床实践。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:45:41 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802349, encodeId=4b698023499b, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>这个研究这个架子的价与我们平时忽视的一些点,你1秒的防护,与糖尿病的关联,虽然疫苗和潭利平之间可能是间接关系,但是对于临泉的指导价值依然很大的这个研究。事实上,如果进一步分析的老年人中接种流感疫苗可能会更大幅度的降低了糖尿病相关的死亡风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:45:07 CST 2020, time=2020-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802348, encodeId=97df802348c0, content=<a href='/topic/show?id=76456533481' target=_blank style='color:#2F92EE;'>#流感疫苗#</a>可能是因为接种了流感疫苗以后,降低了呼吸道并发症的发生,从而减少了糖尿病的并发症并发症的减少,其实带来死亡风险的降低。, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65334, encryptionId=76456533481, topicName=流感疫苗)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Fri Jul 10 20:44:15 CST 2020, time=2020-07-10, status=1, ipAttribution=)]
    2020-07-10 lovetcm

    #流感疫苗#可能是因为接种了流感疫苗以后,降低了呼吸道并发症的发生,从而减少了糖尿病的并发症并发症的减少,其实带来死亡风险的降低。

    0

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