Pediatrics:维生素D对胎儿发育的影响

2015-01-14 MedSci MedSci原创译

过去的出生队列研究表明,胎儿环境对出生后健康状况有影响,这为我们提供了非常宝贵的研究数据。但是目前还不明确维生素D水平对胎儿发育的影响。通过对随机挑选社区内901名母婴,研究者对孕18周时维生素D缺乏展开调查,并研究其子女的长期健康结局。纳入的研究对象为1989-1991年在澳大利亚佩斯、澳大利亚西部出生的儿童。研究发现,孕妇中共有36%患维生素D缺乏,即血清25(OH)D含量小于50nmol/L

过去的出生队列研究表明,胎儿环境对出生后健康状况有影响,这为我们提供了非常宝贵的研究数据。但是目前还不明确维生素D水平对胎儿发育的影响。通过对随机挑选社区内901名母婴,研究者对孕18周时维生素D缺乏展开调查,并研究其子女的长期健康结局。纳入的研究对象为1989-1991年在澳大利亚佩斯、澳大利亚西部出生的儿童。研究发现,孕妇中共有36%患维生素D缺乏,即血清25(OH)D含量小于50nmol/L。在调整了协变量后发现,孕妇怀孕时维生素D缺乏与其子女在6岁时肺发育不良、10岁时神经认知障碍、青少年期饮食障碍以及20岁时峰值骨密度降低都显著相关。总的来说,维生素D可能在胎儿肺、脑、骨骼发育中起到至关重要的作用。过去的动物研究认为,维生素D能够促进器官发育。目前亟需对补充维生素D的孕妇进行随访随机对照研究,长期随访其子女的健康状况,从而判断维生素D缺乏的孕妇是否能够通过补充维生素D来改善子女的健康状况,并确立孕妇血清25(OH)D的最佳浓度。原始出处: Hart, P.H., et al., Vitamin d in fetal development: findings from a b

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    2015-10-02 hbwxf
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    2015-02-27 feather89
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    2015-01-16 neurowu
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    2015-01-14 116.226.156.**

    我们自己

    0

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    2015-01-14 MedSci客户端网友

    可以

    0

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