Clinica Chimica Acta:血清脂蛋白相关磷脂酶A2是一种有前景预后生物标志物,与急性脑出血90天的预后有关

2019-09-22 gladiator MedSci原创

脂蛋白相关磷脂酶A2 (Lp-PLA2)可反映血管炎症,在脑血管疾病的病理生理过程中起重要作用。我们确定血清Lp-PLA2作为脑出血(ICH)预后生物标志物的有效性。

脂蛋白相关磷脂酶A2 (Lp-PLA2)可反映血管炎症,在脑血管疾病的病理生理过程中起重要作用。我们确定血清Lp-PLA2作为脑出血(ICH)预后生物标志物的有效性。

在这项前瞻性观察研究中,研究人员检测164例急性自发性基底神经节出血患者和164例健康对照者血清Lp-PLA2浓度。使用多变量分析,我们分析了在卒中90 天其与较差的预后结果(modified Rankin Scale >2)和出血的严重程度和血肿体积。

研究发现,患者血清Lp-PLA2浓度明显高于对照组。Lp-PLA2浓度与NIHSS 得分(t=5.095, P< 措施)和血肿体积(t=2.850, P=.005)独立相关。在90天的随访中,85名患者(51.8%)的预后较差。在接受者工作特性曲线下,血清Lp-PLA2具有显著的预后判别能力(AUC, 0.813;95%可信区间,0.744-0.869)。血清Lp-PLA2浓度≥304ng / ml是预后不良的独立预测指标(7.052;95%可信区间1.971-25.228)

血清Lp-PLA2浓度的升高与出血严重程度及脑出血后的临床结果密切相关,表明血清Lp-PLA2是脑出血的一种潜在的预后生物标志物。

原始出处:

Lin BianLian-Gang MaoSerum lipoprotein-associated phospholipase A2 as a promising prognostic biomarker in association with 90-day outcome of acute intracerebral hemorrhage

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    2020-02-04 windight
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    2019-09-30 最帅小男护

    学习了

    0

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