Eur Heart J:升高的血压与主动脉瓣疾病风险

2018-09-13 xing.T MedSci原创

由此可见,长期的血压升高与AS和AR风险增加有关,该研究观察到的相关性的可能因果关系值得进一步探究。

近日,血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员旨在验证两个相关的假设,即血压(BP)升高是主动脉瓣狭窄(AS)或反流(AR)的危险因素。

在这项针对540万基线时没有已知血管疾病或主动脉瓣疾病的英国患者队列研究中,研究人员使用多变量调整的Cox回归模型分析了BP与AS和AR事件风险之间的关系。

在中位随访9.2年期间,20680名(0.38%)患者被诊断为AS,6440名(0.12%)患者被诊断为AR。研究人员发现收缩压(SBP)与AS和AR的风险相关,没有115mmHg为最低点的证据。SBP每增加20mmHg,AS风险增加41%(风险比为1.41,95%置信区间为1.38-1.45),AR风险增加38%(1.38,1.31-1.45)。年轻患者的关联性较强,但没有强有力的证据表明性别或体重指数之间存在相互作用。舒张压每增加10mmHg,AS风险增加24%(1.24,1.19-1.29),但AR风险未增加(1.04,0.97-1.11)。脉压每增加15mmHg,AS风险增加46%(1.46,1.41-1.50),AR风险增加53%(1.53,1.45-1.62)。

由此可见,长期的血压升高与AS和AR风险增加有关,该研究观察到的相关性的可能因果关系值得进一步探究。

原始出处:

Kazem Rahimi.et al.Elevated blood pressure and risk of aortic valve disease: a cohort analysis of 5.4 million UK adults. Eur Heart J.2018. https://doi.org/10.1093/eurheartj/ehy486

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    2018-09-15 zhaojie88
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    2018-09-15 slcumt
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    2018-09-13 医者仁心5538

    学习了

    0

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    2018-09-13 13718711b3m

    值得借鉴与学习的临床经验,涨见识,受益匪浅,感谢分享!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1332556, encodeId=0c26133255635, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Sat Sep 15 02:08:00 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356918, encodeId=278d13569186d, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Sep 15 02:08:00 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415372, encodeId=762114153e2e5, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Sat Sep 15 02:08:00 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473141, encodeId=c69c14e31412e, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Sat Sep 15 02:08:00 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478957, encodeId=6b7214e89574e, content=<a href='/topic/show?id=0b0e231986d' target=_blank style='color:#2F92EE;'>#主动脉瓣疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23198, encryptionId=0b0e231986d, topicName=主动脉瓣疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d5cd7466451, createdName=ms3994565386320060, createdTime=Sat Sep 15 02:08:00 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562970, encodeId=d20d15629e0b3, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sat Sep 15 02:08:00 CST 2018, time=2018-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344833, encodeId=c83e34483302, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Thu Sep 13 13:29:42 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344831, encodeId=e3a63448317b, content=值得借鉴与学习的临床经验,涨见识,受益匪浅,感谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/27/c53a212859edcad4f60a54feffff50bb.jpg, createdBy=67cf1525321, createdName=13718711b3m, createdTime=Thu Sep 13 13:14:52 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344826, encodeId=555c34482640, content=好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Thu Sep 13 11:28:48 CST 2018, time=2018-09-13, status=1, ipAttribution=)]
    2018-09-13 lietome15

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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