Circulation:房颤与非ST段抬高心肌梗死(NSTEMI)相关

2015-05-04 MedSci MedSci原创

    最近有报道说,房颤[AF]与心肌梗死[MI]的风险增加有关。然而,这种关联背后的机理目前尚不清楚。未来对心肌梗死[ST段抬高心肌梗死(STEMI)与非ST段抬高心肌梗死(NSTEMI)]的AF患者类型的关系的进一步研究可能揭示潜在机制。    我们从14462参与者[平均年龄54岁,56%为女性,26%的非裔美国人]中研究AF和MI事件的联系,患者来

最近有报道说,房颤[AF]与心肌梗死[MI]的风险增加有关。然而,这种关联背后的机理目前尚不清楚。未来对心肌梗死[ST段抬高心肌梗死STEMI)与非ST段抬高心肌梗死(NSTEMI)]的AF患者类型的关系的进一步研究可能揭示潜在机制。
 
我们从14462参与者[平均年龄54岁,56%为女性,26%的非裔美国人]中研究AF和MI事件的联系,患者来自于动脉粥样硬化风险社区研究,在基线上都没有冠心病[1987-1989],直到2010年12月31日,AF病例是由心电图研究和出院记录的审查确定的。MI事件和其类型是由一个独立的评审委员会确定的。在中位随访时间21.6年中,1374例MI事件发生[829 NSTEMI,249 STEMI,296没有分类]。在一个多变量调整的模型中,AF[n=1545]作为一个随时间变化的变量与MI 63%的风险增加有关[HR(95%Cl):1.63(1.32-2.02)]。然而,AF与NSTEMI相关[HR(95%Cl):1.80(1.39-2.31),但与STEMI无关[HR(95%Cl):0.49(0.18-1.34)];风险比对照p=0.004。无论是STEMI或NSTEMI或没有分类的MI组都没有改变这一结论。AF和MI,总NSTEMI之间的关联是在女性中要强于男性[二者的p值均<0.01]。
 
房颤与心肌梗死风险的增加相关,尤其是女性。然而,这种关联仅限于非ST段抬高心肌梗死(NSTEMI)。
 
原始出处
 
Elsayed Z. Soliman1*; Faye Lopez2; Wesley T. O'Neal1; Lin Y. Chen3; Lindsay Bengtson2; Zhu-Ming Zhang1; Laura Loehr4; Mary Cushman5; Alvaro Alonso2,Atrial Fibrillation and Risk of ST-Segment Elevation versus Non-ST Segment Elevation Myocardial Infarction: The Atherosclerosis Risk in Communities (ARIC) Study,Circulation,2015.4.27

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    2016-04-13 lxg951
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content=<a href='/topic/show?id=9117168e030' target=_blank style='color:#2F92EE;'>#ST段抬高心肌梗死#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16870, encryptionId=9117168e030, topicName=ST段抬高心肌梗死)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=095213453430, createdName=12498636m53(暂无昵称), createdTime=Wed May 06 04:20:00 CST 2015, time=2015-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624327, encodeId=0e94162432ee1, content=<a href='/topic/show?id=f27b16862d9' target=_blank style='color:#2F92EE;'>#ST段#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Wed May 06 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    2015-07-29 drj2003
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04:20:00 CST 2015, time=2015-05-06, status=1, ipAttribution=)]
  5. 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04:20:00 CST 2015, time=2015-05-06, status=1, ipAttribution=)]
    2015-05-06 gdsun
  6. 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  7. 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    2015-05-06 wleon8898
  8. 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    2015-05-06 hyf035

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