Stroke:血清神经红蛋白与动脉瘤性蛛网膜下腔出血患者脑代谢和功能结局相关

2019-06-12 xing.T 网络

由此可见,Ngb可能是反映严重aSAH患者脑组织氧张力、脑代谢和功能结局的潜在生物标志物,值得进一步探究aSAH的功能。

缺氧缺血性脑损伤是动脉瘤性蛛网膜下腔出血(aSAH)后公认的病理生理学机制。神经红蛋白(Ngb)是一种主要在脑中表达的血红蛋白,对氧有很高的亲和力。尚未研究报道aSAH患者血清Ngb水平与脑代谢之间的关系。

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,该研究纳入了连续就诊的36例接受多模式神经监测的严重aSAH患者(入院时格拉斯哥昏迷量表评分≤8)和36名健康受试者。结合其他时间匹配的脑微透析参数、脑组织氧张力和12个月的神经学结局分析血清Ngb水平。 

血清Ngb水平与脑微透析参数和脑组织氧张力呈正相关(P<0.001)。aSAH后12个月功能结局差(改良Rankin量表评分>3)与较高的Ngb水平相关,但与年龄、性别和疾病严重程度无关(P<0.001)。在高Ngb水平和神经心理学测试结局之间发现了类似的关联,表明认知、视觉概念和额叶执行功能的损伤(P<0.001)。 

由此可见,Ngb可能是反映严重aSAH患者脑组织氧张力、脑代谢和功能结局的潜在生物标志物,值得进一步探究aSAH的功能。 

原始出处:

Chen-Yu Ding.et al.Serum Ngb (Neuroglobin) Is Associated With Brain Metabolism and Functional Outcome of Aneurysmal Subarachnoid Hemorrhage.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.025733

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