胸痛患者该做冠脉CT,还是运动试验?JAMA子刊研究

2020-06-09 xujing 文韬 中国循环杂志

对于疑似冠心病的胸痛患者,心电图运动试验是传统检查手段,诊断冠状动脉狭窄的特异性为85%~90%,但目前冠脉CT应用越来越多,二者有何区别?

对于疑似冠心病的胸痛患者,心电图运动试验是传统检查手段,诊断冠状动脉狭窄的特异性为85%~90%,但目前冠脉CT应用越来越多,二者有何区别?

近期,JAMA心脏病学子刊一项研究发现,在运动试验结果正常或不确定的患者中,存在着大量的非梗阻性和有明显狭窄的冠状动脉疾病。

与随后进行有创冠脉造影对照,运动试验诊断冠心病的特异性达91%,但敏感性仅39%。

对于运动试验异常的患者,5年冠心病死亡或非致命性心梗死亡率增加了2.57倍。

但与运动试验相比,冠脉CT可发现更多冠脉病变。而且其与5年冠状动脉事件的相关性更强。

冠脉CT异常者,5年冠心病死亡或非致死性心梗风险增加了10倍。

作者表示,通过冠脉CT,不但使诊断更为明确,还可以更好的采取预防措施,避免发生严重的心血管事件。

研究发现,对于运动试验结果不确定者,冠脉CT的价值更大。

之前该研究组在新英格兰医学杂志发表的该研究证实,对于胸痛的患者,先做冠脉CT可以明显降低胸痛患者的冠心病死亡及心肌梗死风险,同时不增加介入治疗。

该研究分析了3283例接受运动试验和冠脉CT的患者。

冠脉CT中血管明显狭窄的定义使心外膜大血管管腔横截面积狭窄大于70%,或左主干管腔横截面积狭窄大于50%。冠脉正常为<10%,非梗阻为狭窄10%~70%。

来源:

[1]Singh T, Bing R, Dweck MR, et al. Exercise Electrocardiography and Computed Tomography Coronary Angiography for Patients With Suspected Stable Angina Pectoris: A Post Hoc Analysis of the Randomized SCOT-HEART Trial. JAMA Cardiol. 2020.

[2] Coronary CT Angiography and 5-Year Risk of Myocardial Infarction. The SCOT-HEART Investigators. N Engl J Med, 2018, 379: 924-933.

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    2021-09-15 湘雅科教

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    2020-06-11 许安
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    2020-06-09 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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