盘点:阴茎勃起功能障碍研究盘点

2019-05-20 AlexYang MedSci原创

【1】Sci Rep:血清高敏C反应蛋白水平与阴茎勃起功能障碍相关性研究 https://www.nature.com/articles/s41598-019-42342-3炎症能够影响内皮功能并且与阴茎勃起功能障碍(ED)的恶化有关。因此,最近有研究人员在中国男性群体中调查了炎症标记高敏C反应蛋白(hs-CRP)与ED之间的相关性。研究包括了1515名参与者。研究发现,血清hs-CRP水平在


炎症能够影响内皮功能并且与阴茎勃起功能障碍(ED)的恶化有关。因此,最近有研究人员在中国男性群体中调查了炎症标记高敏C反应蛋白(hs-CRP)与ED之间的相关性。

研究包括了1515名参与者。研究发现,血清hs-CRP水平在ED患者中显著更高,并且随着患者ED程度的加重其水平恶性化增加(ptrend<0.001)。在调整后的多变量模型中,最高四分位hs-CRP水平与最低四分位hs-CRP水平患者相比,最高四分位患者ED的可能性增加(OR=1.50; 95% CI=1.08-2.08)。当参与者通过年龄进行分层,ED的风险在中年和老年男性中更加显著。基于ROC分析,血清hs-CRP对ED的预后值较差,AUC为0.58(95% CI: 0.56-0.61),但是在区分重度ED方面具有良好的诊断表现(AUC: 0.79; 95% CI: 0.77-0.81)。

最后,研究人员指出,他们的发现表明了hs-CRP也许在作为评估ED风险时是有用的炎症标记,并且在ED的病因中具有重要作用。


最近,有研究人员评估了男性为什么不会为阴茎勃起功能障碍寻求治疗的可能的原因。

研究总共包括了500名男性。这些男性拜访了他们的家庭医生,并根据他们拜访的原因和他们总的健康状态分成3个不同的小组。研究人员还利用调查问卷来调查每一位参与者关于人生中出现阴茎勃起功能障碍时,寻求治疗的意愿。研究发现,参与者的回答结果的统计学分析表明具有严重的慢性疾病和恶性肿瘤患者对性活动不太感兴趣,并且与健康男性和轻度慢性疾病男性相比,也不太可能去寻求阴茎勃起功能障碍的治疗。另外,研究人员还发现,更高的患者教育水平和安慰能够增加慢性疾病患者和恶性肿瘤患者治疗阴茎勃起功能障碍的比例。


阴茎勃起功能障碍(ED)是糖尿病的一种重要的并发症。最近,有研究人员确定了是否阿魏草(FE)根提取物在链脲霉素(STZ)诱导的糖尿病小鼠中能够影响ED。

研究包括了75只成年雄性小鼠,并均分成5等分;对照组(C)、FE组(40mg/kg-d)、STZ诱导的糖尿病组(60mg/kg)(DM)、糖尿病+阿魏草根组(DM+FE)和乙醇组(EtOH)。8周后,研究人员评估了体外和体内各种参数。研究发现,在STZ诱导的糖尿病组中,乙酰胆碱诱导的内皮细胞依赖的舒张反应以及电场刺激引起的神经源性和硝基能性松弛反应均显著减少,而FE给药糖尿病小鼠则能够恢复减少的硝基能性和神经源性松弛反应。在糖尿病足,ICP/MAP (0.1375±0.02cm/H2O)、睾丸精子发生(53.73±0.81)和睾丸的重量均显著减少;然而,FE给药糖尿病小鼠能够恢复上述减少的值(分别为0.350±0.019cm/H2O, 75.07±0.35和416±24.11)。在DM组,血糖水平与C组比较显著增加(411.7±18.30)。然而,FE给药能够减少血糖水平(230.6±25.60mg/dL)。

最后,研究人员指出,FE能够恢复神经源性和内皮功能紊乱,并减少糖尿病小鼠中血糖的水平。


磷酸二酯酶5型抑制剂(PED5i)在阴茎勃起功能障碍(ED)患者和未确诊的前驱糖尿病(PreDM)患者中的治疗效果还缺乏分析。最近,有研究人员在一个没有经历PED5i治疗的ED患者群体中评估了口服PED5i治疗的响应速度和预测因子,这些患者血糖正常或者PreDM或者患有糖尿病(DM)。

研究包括了466名男性。研究发现,血糖正常、PreDM或者DM的患者比例分别为253 (56.7%)、105 (23.5%)和88 (19.7%)。与对照组相比,糖尿病和PreDM男性年龄更大,BMI更高,CCI得分也更高,而总睾酮更低(p<0.01)。基线IIEF-EF均值与对照组相比,PreD (14.0 vs. 18.0; p<0.05)和DM(10.0 vs. 18.0; p<0.001)显著更低。在治疗后,IIEF-EF在所有的组中均具有显著的改善(p<0.001),但是在3个月时,得分在对照组中要比PreDM或者DM男性更高(分别为26.0 vs. 20.0 vs. 17.5,p<0.001)。对照组获得显著的MCID要比PreDM和DM组频率显著更高(分别为65.3 vs. 22.9 vs. 11.8%,p<0.01)。年龄(p<0.001)、基线IIEF-EF(p<0.001)和DM状态(p=0.02)均与MCID独立相关。

最后,研究人员指出,与血糖正常的男性相比,患有未确诊的前驱糖尿病的患者对PDE5i的响应速度更慢。他们的发现表明了血糖损伤虽小,但仍与ED男性中更差的PED5i效果相关。

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    2019-07-27 habb
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    2019-05-22 dingxiaobo
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最近,有研究人员评估了男性为什么不会为阴茎勃起功能障碍寻求治疗的可能的原因。研究总共包括了500名男性。这些男性拜访了他们的家庭医生,并根据他们拜访的原因和他们总的健康状态分成3个不同的小组。研究人员还利用调查问卷来调查每一位参与者关于人生中出现阴茎勃起功能障碍时,寻求治疗的意愿。研究发现,参与者的回答结果的统计学分析表明具有严重的慢性疾病和恶性肿瘤患者对性活动不太感兴趣,并且与健康男性和轻度慢性

Int J Impot Res:阴茎勃起功能障碍与嗜中性粒细胞与淋巴细胞比例、血小板与淋巴细胞比例之间的关系研究

老龄化男性阴茎勃起功能障碍(ED)的最重要的起因为器官机能疾病,主要是由于动脉硬化引起的血管障碍。之前,有研究表明了动脉硬化能够表现出活跃的炎症过程,而不是因为脂质浸润而引起的消极的血管损伤。最近,有研究人员探究了ED与嗜中性粒细胞与淋巴细胞比例(NLR)和血小板与淋巴细胞比例(PLR)之间的关系,NLR和PLR均为炎症标记。在2014年12月到2015年5月之间,101名年龄在40-70岁的且患