JCEM:血清25-羟基维生素D水平变化对非酒精性脂肪性肝病发生风险和缓解的关系

2022-04-24 MedSci原创 MedSci原创

维持足够的血清25(OH)D浓度可能对NAFLD的预防和缓解都有好处。

维生素D状态对非酒精性脂肪性肝病(NAFLD)风险的保护或致病作用尚未明确。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在评估随访期间血清25-羟基维生素D [25(OH)D]状态的变化与发生NAFLD的风险和已患NAFLD缓解之间的关系。

该回顾性队列研究是基于常规健康筛检,参与者为韩国成年人(平均年龄为36.8岁;年龄范围18-96岁),他们接受全面健康检查,包括血清25(OH)D水平的评估。该研究的主要结局指标为a)NAFLD的发生率和b)肝脏超声评估的NAFLD缓解情况。Cox比例风险模型用于根据血清25(OH)D水平估计结局的风险比(HR)和95%置信区间(CIs)。

在139599名基线时没有NAFLD的参与者中,27531人在随访期间发生了NAFLD。血清25(OH)D水平与NAFLD的发生呈显著负相关。在48702名基线伴有NAFLD患者中,有13449名患者的NAFLD缓解。25(OH)D为10-20、20-30和≥30 ng/mL与<10 ng/mL个体相比,NAFLD缓解的多变量调整HR (95%CI)分别为1.09(1.03-1.15)、1.13(1.06-1.21)和1.21(1.09 - 1.35)。此外,从基线到后续随访期间(中位数为1.8年)25(OH)D水平的升高与NAFLD发病率的降低相关,而持续充足的25(OH)D水平与NAFLD发病率的降低和NAFLD的缓解相关。

由此可见,维持足够的血清25(OH)D浓度可能对NAFLD的预防和缓解都有好处。

原始出处:

Yejin Kim,et al.Resolution of, and risk of incident non-alcoholic fatty liver disease with changes in serum 25-hydroxy vitamin D status.JCEM.2022.https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgac255/6572794?redirectedFrom=fulltext

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    2022-06-04 smallant2015
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    2022-11-10 achengzhao
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    2022-05-02 qjddjq
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