Gastroenterology:心理压力与肝病死亡率关系-meta分析

2015-02-28 詹柱 MedSci原创

心脑血管疾病与非酒精性脂肪肝具有相关性,如肥胖症和高血压。而心理压力(焦虑和抑郁的症状)是心脑血管疾病的危险因素,因此,心理压力可能直接或间接地与肝病相关。我们通过这项研究调查了心理压力与肝病死亡率的关系,心理压力通过12项一般健康问卷(General Health Questionnaire GHQ)来评估衡量。 方法 我们进行了一项meta分析,数据来自于从1994年到2009年美国一般人

心脑血管疾病与非酒精性脂肪肝具有相关性,如肥胖症和高血压。而心理压力(焦虑和抑郁的症状)是心脑血管疾病的危险因素,因此,心理压力可能直接或间接地与肝病相关。我们通过这项研究调查了心理压力与肝病死亡率的关系,心理压力通过12项一般健康问卷(General Health Questionnaire GHQ)来评估衡量。

方法

我们进行了一项meta分析,数据来自于从1994年到2009年美国一般人群的16项前瞻性研究中的单独个体参与者,受试者均采用GHQ评分进行分组:0分(没有压力),1-3分,4-6分,7-12分。

结果

我们共分析了166631个人,其中55%为女性,年龄46.6±18.4岁,从16岁到102岁不等。在平均9.5年的随访期间,有17368个受试者死亡(457例患者死于肝病)。我们发现随着GHQ评分增加,肝病死亡率明显增加(Ptrend<.001)。经过年龄和性别匹配,最高GHQ评分(7-12分)与最低GHQ评分(0分)的危险比为3.48。随着健康行为、社会经济地位、体重指数和糖尿病的改善,上述危险比降低至2.59。

结论

虽然这项研究需要进行更多的分析,但基于这项meta分析,心理压力与肝病死亡率有相关性。虽说心理压力不太可能会引起肝病死亡率增加,但我们提供了进一步的证据,表明心理问题对身体健康的有害影响。

原始出处

Russ TC1, Kivimäki M2, Morling JR3, Starr JM4, Stamatakis E5, Batty GD6.Association Between Psychological Distress and Liver Disease Mortality: a Meta-analysis of Individual Study Participants.Gastroenterology. 2015 Feb 10

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    2015-11-23 许安
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    2015-05-13 一闲
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    2015-04-17 guojianrong
  6. [GetPortalCommentsPageByObjectIdResponse(id=2071575, encodeId=894020e15757f, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Nov 23 13:48:00 CST 2015, time=2015-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710787, encodeId=f74a1e107876b, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Dec 31 13:48:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063918, encodeId=00a120639182f, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Jun 16 05:48:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895784, encodeId=ef991895e84de, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed May 13 00:48:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887427, encodeId=369d188e427a1, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Apr 17 11:48:00 CST 2015, time=2015-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17970, encodeId=c28d1e97056, content=从另外一个角度分析了肝病的诱发因素,挺好, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=109f1616069, createdName=DoctorTao1991, createdTime=Sun Mar 08 21:33:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504202, encodeId=368615042021d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Mon Mar 02 04:48:00 CST 2015, time=2015-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630809, encodeId=b43b1630809fb, content=<a href='/topic/show?id=96875113eb4' target=_blank style='color:#2F92EE;'>#心理压力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51137, encryptionId=96875113eb4, topicName=心理压力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3e721584542, createdName=yuanming14, createdTime=Mon Mar 02 04:48:00 CST 2015, time=2015-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17254, encodeId=72351e25437, content=如何获得数据?, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=117.136.8.**, createdTime=Sat Feb 28 19:33:00 CST 2015, time=2015-02-28, status=1, ipAttribution=)]
    2015-03-08 DoctorTao1991

    从另外一个角度分析了肝病的诱发因素,挺好

    0

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  8. [GetPortalCommentsPageByObjectIdResponse(id=2071575, encodeId=894020e15757f, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Nov 23 13:48:00 CST 2015, time=2015-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710787, encodeId=f74a1e107876b, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Dec 31 13:48:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063918, encodeId=00a120639182f, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Jun 16 05:48:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895784, encodeId=ef991895e84de, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed May 13 00:48:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887427, encodeId=369d188e427a1, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Apr 17 11:48:00 CST 2015, time=2015-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17970, encodeId=c28d1e97056, content=从另外一个角度分析了肝病的诱发因素,挺好, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=109f1616069, createdName=DoctorTao1991, createdTime=Sun Mar 08 21:33:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504202, encodeId=368615042021d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Mon Mar 02 04:48:00 CST 2015, time=2015-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630809, encodeId=b43b1630809fb, content=<a href='/topic/show?id=96875113eb4' target=_blank style='color:#2F92EE;'>#心理压力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51137, encryptionId=96875113eb4, topicName=心理压力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3e721584542, createdName=yuanming14, createdTime=Mon Mar 02 04:48:00 CST 2015, time=2015-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17254, encodeId=72351e25437, content=如何获得数据?, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=117.136.8.**, createdTime=Sat Feb 28 19:33:00 CST 2015, time=2015-02-28, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=2071575, encodeId=894020e15757f, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Mon Nov 23 13:48:00 CST 2015, time=2015-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710787, encodeId=f74a1e107876b, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Thu Dec 31 13:48:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2063918, encodeId=00a120639182f, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Tue Jun 16 05:48:00 CST 2015, time=2015-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895784, encodeId=ef991895e84de, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed May 13 00:48:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887427, encodeId=369d188e427a1, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Apr 17 11:48:00 CST 2015, time=2015-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17970, encodeId=c28d1e97056, content=从另外一个角度分析了肝病的诱发因素,挺好, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=109f1616069, createdName=DoctorTao1991, createdTime=Sun Mar 08 21:33:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504202, encodeId=368615042021d, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Mon Mar 02 04:48:00 CST 2015, time=2015-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630809, encodeId=b43b1630809fb, content=<a href='/topic/show?id=96875113eb4' target=_blank style='color:#2F92EE;'>#心理压力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51137, encryptionId=96875113eb4, topicName=心理压力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a3e721584542, createdName=yuanming14, createdTime=Mon Mar 02 04:48:00 CST 2015, time=2015-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17254, encodeId=72351e25437, content=如何获得数据?, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=117.136.8.**, createdTime=Sat Feb 28 19:33:00 CST 2015, time=2015-02-28, status=1, ipAttribution=)]
    2015-02-28 117.136.8.**

    如何获得数据?

    0

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