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PLoS One：他汀类可调节CD147来下调单核细胞的分化

2018-01-16 MedSci MedSci原创

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CD147是活化诱导的糖蛋白，可促进基质金属蛋白酶（MMP）的分泌和活化，并在巨噬细胞分化过程中上调。有趣的是，CD147的一些分子功能依赖于其糖基化状态：CD147的高度糖基化形式诱导MMPs，而低度糖基化形式抑制MMPs活化。他汀类是羟甲基戊二酰辅酶A还原酶抑制剂，阻断甲羟戊酸的合成，从而抑制所有甲羟戊酸依赖的途径，包括异戊二烯化，N-糖基化和胆固醇合成。在这项研究中，研究人员探究了他汀类药物

CD147是活化诱导的糖蛋白，可促进基质金属蛋白酶（MMP）的分泌和活化，并在巨噬细胞分化过程中上调。有趣的是，CD147的一些分子功能依赖于其糖基化状态：CD147的高度糖基化形式诱导MMPs，而低度糖基化形式抑制MMPs活化。他汀类是羟甲基戊二酰辅酶A还原酶抑制剂，阻断甲羟戊酸的合成，从而抑制所有甲羟戊酸依赖的途径，包括异戊二烯化，N-糖基化和胆固醇合成。

在这项研究中，研究人员探究了他汀类药物通过调节CD147抑制巨噬细胞分化和MMP分泌相关过程的作用。结果发现，人单核细胞系THP-1向巨噬细胞表型的分化导致CD147和CD14的上调，并且这种作用被抑制素抑制。在分子水平，抑制素通过抑制异戊二烯化和N-糖基化来改变CD147的表达、结构和功能。此外，他汀类药物诱导CD147从其高度糖基化形式转变为低度糖基化形式。这种N-糖基化状态的改变伴随着MMP-2和MMP-9的产生和功能活性的降低。

总之，这些发现描述了他汀类药物免疫调节的新型分子机制，或可用于自身免疫性疾病的治疗。

原始出处：

Sasidhar MV, Chevooru SK, et al., Downregulation of monocytic differentiation via modulation of CD147 by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. PLoS One. 2017 Dec 18;12(12):e0189701. doi: 10.1371/journal.pone.0189701. eCollection 2017.

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    2018-02-09 一叶知秋

    #CD14#

    0

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    2018-11-06 119337457

    #Plos one#

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    2018-01-18 雕雕

    #单核细胞#

    0

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    2018-01-16 周周人

    学习.

    0

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    2018-01-16 神功盖世

    阅

    0