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GUT：虫草多糖通过调节肠道菌群变化改善肥胖及II型糖尿病小鼠症状

2018-07-16 zhangfan MedSci原创

肥胖糖尿病虫草多糖
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研究认为虫草多糖以及P.goldsteinii肠杆菌具有治疗肥胖及II型糖尿病的潜力

冬虫夏草(Ophiocordycecepsinensis)及其无形性变体中国被毛孢(Hirsutella Sinensis)因其免疫调节特性在传统中药中有着悠久的应用历史。肠道微生物群改变在肥胖症和II型糖尿病中发挥了关键作用。近日研究人员考察了虫草菌丝（HSM）及其多糖提取物对饮食导致的肥胖及II型糖尿病的预防效果。

研究人员在高脂饮食小鼠(HFD)模型中考察HSM或多糖提取物的疗效，通过水平粪便微生物移植(FMT)、抗生素治疗和16S rDNA微生物群分析考察虫草对肥胖模型小鼠肠道微生物的影响。

研究发现，高分子量多糖提取物(>300kDa) 可减少高脂小鼠体重（减少50%）以及代谢障碍，其效果与脂肪组织中热发生蛋白标记物的表达增加、肠道完整性增强、肠道和全身炎症减少、胰岛素敏感性增加和脂代谢改善有关。肠道微生物分析显示虫草多糖可选择性的促进Parabacteroides goldsteinii类肠杆菌生长，该菌种已被证实与肥胖负相关。FMT联合抗生素治疗显示新霉素敏感性菌群与肥胖负相关，是虫草抗肥胖作用中的关键因素。HFD小鼠直接受活P. goldsteinii喂养可降低体重，增加脂肪组织发热量，增强肠道完整性，减少炎症和胰岛素抵抗。

研究认为虫草多糖以及P.goldsteinii肠杆菌具有治疗肥胖及II型糖尿病的潜力。

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createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:25 CST 2018, time=2018-07-25, status=1, ipAttribution=)]
    2018-09-15 jyzxjiangqin

    冬虫夏草的影响。

    0

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    2018-09-02 jyzxjiangqin

    虫草多糖通过调节肠道菌群变化改善肥胖。

    0

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25 09:24:33 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334042, encodeId=13a53340420d, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:30 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334041, encodeId=1e4933404144, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:25 CST 2018, time=2018-07-25, status=1, ipAttribution=)]
    2018-07-30 jyzxjiangqin

    虫草多糖调节肠道菌群。

    0

  4. 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25 09:24:33 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334042, encodeId=13a53340420d, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:30 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334041, encodeId=1e4933404144, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:25 CST 2018, time=2018-07-25, status=1, ipAttribution=)]
    2018-07-30 jyzxjiangqin

    虫草多糖的作用。

    0

  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334046, encodeId=f9103340460e, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:44 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334045, encodeId=dc8a33404569, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:40 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334044, encodeId=2c38334044e2, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:37 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334043, encodeId=43dc3340431c, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:33 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334042, encodeId=13a53340420d, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:30 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334041, encodeId=1e4933404144, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:25 CST 2018, time=2018-07-25, status=1, ipAttribution=)]
    2018-07-25 xiaotao112411

    学习学习学习

    0

  6. 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time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334044, encodeId=2c38334044e2, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:37 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334043, encodeId=43dc3340431c, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:33 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334042, encodeId=13a53340420d, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:30 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334041, encodeId=1e4933404144, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:25 CST 2018, time=2018-07-25, status=1, ipAttribution=)]
    2018-07-25 xiaotao112411

    学习学习学习

    0

  7. 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25 09:24:33 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334042, encodeId=13a53340420d, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:30 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334041, encodeId=1e4933404144, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Wed Jul 25 09:24:25 CST 2018, time=2018-07-25, status=1, ipAttribution=)]
    2018-07-25 xiaotao112411

    学习学习学习

    0

  8. 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    学习学习学习

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    2018-07-25 xiaotao112411

    学习学习学习

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