JAHA:2型糖尿病患者主动脉瘤和主动脉夹层的长期风险降低!

2018-01-25 xing.T MedSci原创

由此可见,与CS相比,T2DM患者AA和AD的风险显著降低,AA住院后死亡率也有所降低。数据表明主动脉组织中的糖化交联可能在T2DM患者主动脉病变进展中发挥保护作用。

在2型糖尿病(T2DM)患者中,没有研究评估主动脉瘤(AA)和主动脉夹层(AD)的长期风险或AA、AD住院患者的死亡率。近日,心血管疾病领域权威杂志JAHA上针对这一问题发表了一篇研究文章。

在这项观察性队列研究中,研究人员链接到了瑞典国家糖尿病登记中心得到了2型糖尿病患者和5个无糖尿病的匹配的(基于性别、年龄和县区)基于人口的对照者(CSs)的数据,并联系到其他全国数据库以获取住院和死亡病例。研究人员使用卡普兰曲线和Cox回归风险模型评估了AA和AD的住院风险以及AA和AD的死亡风险。

研究人员获得了448319例T2DM患者和2251015例CSs1998年至2015年期间的资料。T2DM患者平均随访时间为7年,CS组为7.2年。相比于CS组,T2DM患者发生AA的相对风险度降低了28%(风险比为0.72、95%可信区间为0.68-0.76、P<0.0001),发生AD的相对危险度降低了47%(风险比为0.53、95%可信区间为0.42-0.65、P<0.0001)。T2DM患者AA住院后死亡的相对危险度降低了12%(风险比为0.88,95%可信区间为0.82-0.94,P<0.0001),发生AD后死亡率没有改变(风险比为1.07,95%可信区间为0.85-1.34,P=0.5859),直至随访2年与CSs相比。

由此可见,与CS相比,T2DM患者AA和AD的风险显著降低,AA住院后死亡率也有所降低。数据表明主动脉组织中的糖化交联可能在T2DM患者主动脉病变进展中发挥保护作用。

原始出处:


Tarik Avdic,et al. Reduced Long‐Term Risk of Aortic Aneurysm and Aortic Dissection Among Individuals With Type 2 Diabetes Mellitus: A Nationwide Observational Study.JAHA.2018. http://jaha.ahajournals.org/content/7/3/e007618

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    2018-01-28 天地飞扬

    学习一下.谢谢分享!

    0

  3. 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    2018-01-27 zhaohui6731
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  5. 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  6. 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  7. 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    2018-01-26 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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