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Circulation：高灵敏度肌钙蛋白T（hs-cTNT）与高血压事件相关

2015-08-29 崔倩 译 MedSci原创

hs-cTnT高血压
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高血压往往先于心脏结构异常发生。因此，研究人员评估了高灵敏度肌钙蛋白T（hs-cTNT）是否可以作为慢性亚临床心肌损伤标志物，以及可以确认人群是否处于高血压或左心室肥厚（LVH）的危险中。研究人员研究了6,516名ARIC研究的参与者，并且流行性高血压没有流行性高血压和心血管疾病（1990- 1992年）。研究人员检测了基线hs-cTNT类别和诊断高血压事件（在最高19.9年随访期间的诊断和药物使

高血压往往先于心脏结构异常发生。因此，研究人员评估了高灵敏度肌钙蛋白T（hs-cTNT）是否可以作为慢性亚临床心肌损伤标志物，以及确认人群是否处于高血压或左心室肥厚（LVH）的危险中。

研究人员研究了6,516名ARIC研究的参与者，并且流行性高血压没有流行性高血压和心血管疾病（1990- 1992年）。研究人员检测了基线hs-cTNT类别和诊断高血压事件（在最高19.9年随访期间的诊断和药物使用自我报告进行定义）以及与访问为基础的高血压事件的联系（通过在6年过程中自我报告，药物的使用，或测量血压>140/90 mmHg进行定义）。相对于hs-cTNT< 5ng/L时，诊断高血压调事件的整风险比分别为，hs-cTNT 5-8ng/L人群为1.16（95％Cl：1.08，1.25），hs-cTNT 9-13ng/L人群为1.29（1.14，1.47），hs-cTNT ≥14ng/L人群为1.31（1.07，1.61）（p-trend<0.001）。这些联系对于以拜访为基础的高血压关联性较强。这些联系在血压正常的人群中通过较高的相对风险进行驱使（相对于那些高血压前期人群，p-interaction=0.001）驱动。通过超过6年的心电图表明，基线hs-cTNT也与LVH事件相关（如调整后的HR：hs-cTNT≥14ng/ L vs <5ng/ L为5.19[1.49-18.08]为）。在考虑到竞争性死亡或调整基线BP水平或NT-proBNP，研究结果没有改变。

在没有心血管疾病病史的门诊人群中，hs-cTNT与高血压事件和LVH风险相关。还需要进一步研究以确定hs-cTNT是否能够识哪些人群可以从动态血压监测或高血压的预防生活方式策略中受益。

原始出处：

John W. McEvoy,Yuan Chen,Vijay Nambi,et al.High-Sensitivity Cardiac Troponin T and Risk of Hypertension,Circulation,2015.8.26

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    2015-10-27 ms1467340776200723

    #cTnT#

    0

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    2015-10-16 respect

    #灵敏度#

    0

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    2015-08-31 zhouqu_8

    #hs-cTnT#

    0

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    2015-08-31 huangdf

    #肌钙蛋白T#

    0

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