中国中医药信息杂志:电针对血管性认知障碍大鼠学习记忆能力及脑组织炎症因子的影响

2018-07-10 佚名 中国中医药信息杂志

观察电针对血管性认知障碍(VCI)大鼠学习记忆能力和大脑皮层炎症因子的影响,探讨针刺防治VCI的作用机制。

目的 观察电针对血管性认知障碍(VCI)大鼠学习记忆能力和大脑皮层炎症因子的影响,探讨针刺防治VCI的作用机制。

方法 采用颈内动脉微栓子体外注入法制备VCI大鼠模型。将成模大鼠随机分为模型组、阳性药组和电针组,同时取正常大鼠作为对照组。造模3 d后,阳性药组给予盐酸多奈哌齐药液灌胃,电针组针刺“百会”“足三里”。治疗结束后,采用Morris水迷宫检测大鼠学习记忆能力,ELISA检测大鼠脑组织肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-1β的含量。

结果 定位巡航实验随训练次数的增加,阳性药组和电针组大鼠寻找平台平均逃避潜伏期较模型组均有不同程度的缩短;空间探索实验阳性药组和电针组较模型组首次穿越平台所需时间显着缩短;与对照组比较,模型组TNF-α、IL-6、IL-1β含量显着升高;与模型组比较,阳性药组和电针组TNF-α、IL-6、IL-1β含量均显着降低。

结论 电针“百会”“足三里”可能通过降低VCI大鼠大脑皮层TNF-α、IL-6和IL-1β的含量,改善大鼠学习记忆能力。

原始出处:
冯琪,尚华杰,刘美琪,等.电针对血管性认知障碍大鼠学习记忆能力及脑组织炎症因子的影响[J].中国中医药信息杂志,2018,25(6):39-43.DOI:10.3969/j.issn.1005-5304.2018.06.010

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    2019-01-06 yulin2015
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    2018-07-12 cathymary
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    2018-07-12 yahu
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