Int J Epidemiol:1988年-2012年全球儿童中枢神经系统肿瘤发病率的趋势变化

2020-11-24 Nebula-Qin MedSci原创

全球,中枢神经系统(CNS)肿瘤约占儿童癌症的20%。随着科技的进展、医学的进步、生活环境的改善等等,儿童CNS肿瘤的发生率是否随着时间的推移、地域的不同而有所变化?

全球,中枢神经系统(CNS)肿瘤约占儿童癌症的20%。随着科技的进展、医学的进步、生活环境的改善等等,儿童CNS肿瘤的发生率是否随着时间的推移、地域的不同而有所变化?

纳入年龄标准化发病率分析的地域国家

研究人员在五大洲癌症(CI5)数据库中检索CNS肿瘤,根据地域评估0-19岁儿童的年龄标准化的发生率(ASR,例/100万)、男女发生率比(IRR)和平均年化发生率的变化(AAPC)。纳入的肿瘤有:星形细胞瘤、成神经管细胞瘤、室管膜瘤、少突胶质细胞瘤和混合性胶质瘤、不明来源的胶质瘤和其他胚胎性肿瘤。

不同地域不同肿瘤的ASR

本次分析共纳入了56468例CNS肿瘤。2012年全球星形细胞瘤的ASR最高(5.83,95% CI 5.68-5.99)。

不同地域星形细胞瘤的男女发生率比

在全球范围内,本次分析的肿瘤的发病率都是男多于女。从区域上看,只有成神经管细胞瘤的男女比(IRR)持续升高,在1.4-2.2之间。

全球估计AAPC发病率

在 广义评估方程(GEE)模型中,星形细胞瘤的全球发生率降低(AAPC:-1.66),而成神经管细胞瘤、室管膜瘤、不明来源的胶质瘤和其他胚胎性肿瘤的发生率增加(AAPC分别是0.66、1.49、4.76和3.58)。

地域之间存在一定的发病率差异。从低人类发展指数(HDI)进入到高HDI的国家的CNS肿瘤儿童发病率未出现随时间推移的变化。

原始出处:

Williams Lindsay A,Hubbard Aubrey K,Scheurer Michael E et al. Trends in paediatric central nervous system tumour incidence by global region from 1988 to 2012. Int J Epidemiol, 2020.

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    2020-11-24 BJying

    #儿童# #中枢神经系统# #肿瘤# 儿童中枢神经系统(CNS)肿瘤地域之间存在一定的发病率差异,从低人类发展指数(HDI)进入到高HDI的国家的CNS肿瘤儿童发病率未出现随时间推移的变化。

    0

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    2020-11-24 Oranhyg

    胶质瘤作为恶性肿瘤,值得重视

    0

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