J Pain Res:进行阴囊内外科手术的患者精索阻滞时加入右美托咪定的效果:随机对照的多中心临床试验

2018-01-29 余晓旭 “罂粟花”微信号

本研究的目的是探讨追加右美托咪定 (DEX)于使用布比卡因的精索阻滞和术后镇痛的效果。

背景与目的:本研究的目的是探讨追加右美托咪定 (DEX)于使用布比卡因的精索阻滞和术后镇痛的效果。

方法:120名计划择期进行阴囊内外科手术的成年男性,患者被分为两组:B组使用10ml  0.25%布比卡因做精索阻滞,静脉注射50μg右美托咪定,BD组10ml  0.25%布比卡因加入50μg的右美托咪定(9.5ml 0.25%布比卡因+0.5 mL 50μ g右美托咪定)用于精索阻滞,为了掩饰目的,患者静脉注射了生理盐水。在术后的24小时内第一次要求镇痛的时间、止痛剂的用量和视觉模拟量表(瓦斯)疼痛评分用于评估。

结果:第一个要求镇痛的时间BD组与B组相比显着延迟,中位数(四分位距)范围,7(6-12)小时比上6(5 -7)小时,(p = 0.000),术后第一个24h的平均吗啡累计消耗量(mg)BD组与B组相比,8.13± 4.45比12.7±3.79,平均差(95% CI)为-4.57(-6.06 比- 3.07)(p = 0.000);显着降低,疼痛评分BD组与B组相比,在所有测试时间点也显着降低, 2小时为(1.28± 0.9 vs 1.92± 0.8), 6小时为(2.62±1.5 vs 3.93±1.2),12小时为(2.40±1.1、3.57±- 0.65), 24小时为(1.90±- 0.68、2.53±-0.62)(p = 0.000)。

结论:在使用0.25%的布比卡因做精索阻滞的阴囊内手术时加入50μg的右美托咪定,可延迟第一次加止痛剂的时间,减少了术后止痛剂的用量,并提高阻滞的成功率。

原始出处:

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    2018-03-01 amyloid
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    2018-04-07 vera_1210
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    2018-01-31 戒馋,懒,贪

    谢谢分享学习了

    0

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    2018-01-29 hhh678

    henhao

    0

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