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Nat Commun：病毒也能治脑瘤

2019-05-30 晋楠 中国科学报

病毒脑瘤
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《自然—通讯》5月28日发表的一项研究称，一种溶瘤病毒（靶向癌细胞的病毒）有效延长了两种不同类型儿童脑肿瘤模型小鼠的存活时间。这些发现促使研究人员利用该病毒展开一项长期临床试验。

《自然—通讯》5月28日发表的一项研究称，一种溶瘤病毒（靶向癌细胞的病毒）有效延长了两种不同类型儿童脑肿瘤模型小鼠的存活时间。这些发现促使研究人员利用该病毒展开一项长期临床试验。

儿童脑肿瘤如高级别胶质瘤和弥漫内生性脑桥胶质瘤难以治疗，而且与成人肿瘤相比具有遗传差异性。高级别胶质瘤患者的治疗方法是手术、放疗和化疗，但是手术不适合患有弥漫内生性脑桥胶质瘤的儿童患者。美国食品与药物管理局已经批准将溶瘤病毒用于治疗黑素瘤，而且现已表明，Delta-24-RGD病毒对胶质瘤成年患者有效且安全。

西班牙纳瓦拉健康研究所的Marta Alonso及同事利用高级别胶质瘤和弥漫内生性脑桥胶质瘤模型小鼠，检验Delta-24-RGD病毒的有效性。他们发现与未经治疗的小鼠相比，在4种不同癌症模型中，实验小鼠的存活时间延长了。而且在长期存活的小鼠中未检测到病毒蛋白，这意味着这种方法是安全的。

进一步研究表明，病毒在小鼠体内触发了免疫响应，这意味着免疫系统的激活促成了抗癌响应。以上发现表明，这种方法或能用于治疗患有此类肿瘤的儿童患者，但这一点还需要试验验证。

原始出处：

Naiara Martínez-Vélez, Marc Garcia-Moure, Marta M. Alonso, et.al. The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models. Nature Communications 28 May 2019

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    2020-04-22 liye789132251

    #Nat#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1883717, encodeId=d3681883e17ce, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Apr 22 08:30:00 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087550, encodeId=0e8a208e55000, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat Mar 21 12:30:00 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275711, encodeId=f2ec12e571137, content=<a href='/topic/show?id=aad38494640' target=_blank style='color:#2F92EE;'>#脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84946, encryptionId=aad38494640, topicName=脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Sat Jun 01 07:30:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367011, encodeId=694136e011d8, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu May 30 18:56:47 CST 2019, time=2019-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367009, encodeId=010136e00936, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Thu May 30 18:33:05 CST 2019, time=2019-05-30, status=1, ipAttribution=)]
    2020-03-21 liuli5079

    #COMMUN#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1883717, encodeId=d3681883e17ce, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Apr 22 08:30:00 CST 2020, time=2020-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087550, encodeId=0e8a208e55000, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sat Mar 21 12:30:00 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275711, encodeId=f2ec12e571137, content=<a href='/topic/show?id=aad38494640' target=_blank style='color:#2F92EE;'>#脑瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84946, encryptionId=aad38494640, topicName=脑瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373a131, createdName=jxrzshh, createdTime=Sat Jun 01 07:30:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367011, encodeId=694136e011d8, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu May 30 18:56:47 CST 2019, time=2019-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367009, encodeId=010136e00936, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/2EVCwc9WmQS6ec99H2TX8ejmR40xYjwrIcrqjAnibV36aicL1sLxc21rhpZnqTOxk33HP44iayEwo6qYXqgZvdRtA/132, createdBy=d0d01573846, createdName=329523732, createdTime=Thu May 30 18:33:05 CST 2019, time=2019-05-30, status=1, ipAttribution=)]
    2019-06-01 jxrzshh

    #脑瘤#

    0

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    2019-05-30 orangesking

    好

    0

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    2019-05-30 329523732

    不错

    0

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