J Cosmet Dermatol:局部使用VC-IP霜可减少与皮肤老化有关的口周皱纹

2022-08-19 MedSci原创 MedSci原创

众所周知,四异棕榈酰抗坏血酸(VC-IP)是一种油溶性维生素C衍生物,可有效治疗由氧化压力引起的皮肤光老化。此外,众所周知,随着年龄的增长,面部皮肤会发生形态上的变化,而主要原因可能是光老化。

众所周知,四异棕榈酰抗坏血酸(VC-IP)是一种油溶性维生素C衍生物,可有效治疗由氧化压力引起的皮肤光老化。此外,众所周知,随着年龄的增长,面部皮肤会发生形态上的变化,而主要原因可能是光老化。目前还没有任何公开报道研究维生素C衍生物对眶周皱纹的临床效果。近日,发表于J Cosmet Dermatol的一项双盲、随机、安慰剂对照的分脸临床试验探究了VC-IP的潜在抗皱效果。

研究纳入了23名女性受试者,随机分为3组,分别使用1%、2%或3%的VC-IP霜与安慰剂霜来治疗面部皱纹。将VC-IP霜涂抹在每个受试者一侧面部的口周区域,每天两次,持续8周,另一侧则涂抹安慰剂面霜。通过视觉皱纹分级和地形评估来评估抗皱效果。

 

结果显示,根据视觉观察和照片分级,使用VC-IP每天两次治疗8周的眶部皱纹有明显或中等程度的改善。此外,形貌评估证实了VC-IP的改善效果。值得一提的是,效果的改善因VC-IP的浓度而异。此外,据报道,在较低浓度的VC-IP中,与皮肤结构有关的参数也得到了明显的改善。

根据研究人员既往的研究结果显示,VC-IP具有很高的皮肤渗透性,所以可有效改善真皮层的深层皱纹,即使是1%的VC-IP的低浓度,但是对于受组织变化影响的显著形态变化预计3%VC-IP的有效性更高。总之,该研究结果表明,局部使用VC-IP霜可减少与皮肤老化有关的口周皱纹。然而,需要在临床试验中进一步研究其与皮肤内部结构的关系,以阐明VC-IP抗皱作用的确切机制。

 

原始出处:

 

Mariko YokotaShoichi Yahagi. Evaluation of the anti-wrinkle effect of a lipophilic pro-vitamin C derivative, tetra-isopalmitoyl ascorbic acid. J Cosmet Dermatol. 2022 Aug;21(8):3503-3514. doi: 10.1111/jocd.14604.  

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    2023-06-01 一闲
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    2023-03-06 tcm99hq
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    2022-08-19 emmmm!

    值得学习

    0

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    2022-08-16 gujh
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    2022-08-16 chg122

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