2012EASO-ESH+联合声明-肥胖和难治性动脉高血压:控制体重的降压获益是否被高估了?

2012-06-19 王丽 中国医学论坛报

       近期,欧洲肥胖症研究学会(EASO)和欧洲高血压学会(ESH)共同发表了肥胖和难治性动脉高血压联合声明,声明中指出,肥胖症患者易于罹患高血压,常需要更多降压药物治疗,此类患者难治性高血压风险增加。        肥胖和高血压常并存于同一患者,二者间的关联可能因遗传机制等表现出较大的个体差异。肥胖影响

       近期,欧洲肥胖症研究学会(EASO)和欧洲高血压学会(ESH)共同发表了肥胖和难治性动脉高血压联合声明,声明中指出,肥胖症患者易于罹患高血压,常需要更多降压药物治疗,此类患者难治性高血压风险增加。

       肥胖和高血压常并存于同一患者,二者间的关联可能因遗传机制等表现出较大的个体差异。肥胖影响患者所有心血管和代谢风险,但肥胖与心血管风险间的相关性较复杂,临床指南对此尚未充分阐明。该声明从病理生理、流行病学和临床等多角度对肥胖和高血压的关系进行了综述,旨在梳理现有成果,探寻有待进一步深入研究的领域及聚焦此类患者的治疗困境。

       声明指出,控制体重是降压常见的推荐策略,但当前的高血压指南并未针对如何进行控制体重提供基于证据的推荐。总体来讲,可能由于相关研究是基于短期减重的结果,故减重对血压的影响有可能被高估。实际上,在减重期、体重维持期和后续体重反弹不同阶段血压可能都会发生变化。此外,个体减重对血压的影响各异,且依赖于其基线血压水平。减重对血压的影响可能因其他并存因素而减弱,如能量平衡、饮食构成,体育锻炼、并存疾病及药物治疗情况等。总之,在大多数肥胖相关研究中,血压并非主要观察结果,故并未被适当测量。然而,在严重肥胖患者中,通过外科手术减重显示出可使患者心血管事件发生风险下降的益处。

       怎样把控制体重策略和降压治疗结合起来,使患者获得最优的临床结局,目前仍无定论。

    点击下载:2012EASO-ESH+联合声明-肥胖和难治性动脉高血压.pdf

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    2012-09-05 huangdf
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    2012-06-21 wfang549
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    2012-06-21 freve

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