Blood:NCOA4介导失血后的肝铁储备动员

2020-07-22 MedSci原创 MedSci原创

NCOA4介导失血后的肝铁储备动员;在促进HIF稳定的条件下,NCOA4表达以HIF-1α/HIF-2α依赖性方式上调。

中心点:

NCOA4介导失血后的肝铁储备动员;

在促进HIF稳定的条件下,NCOA4表达以HIF-1α/HIF-2α依赖性方式上调。

摘要:

放血促进肝铁储备动员的机制尚不明确。NCOA4(核受体共激活因子4)是一种广泛表达的细胞内蛋白,已被证明可以介导铁蛋白的自噬降解。在本研究中,Li等研究了NCOA4在调节肝脏铁储备中的局部需求以及NCOA4的调节机制。

在未放血的小鼠中,靶向敲除肝细胞的Ncoa4基因对肝脏铁蛋白亚单位水平和非血红素铁浓度的影响不大。放血后,靶向敲除肝细胞Ncoa4基因的小鼠出现贫血和低铁血症,与Ncoa4调节完整的对照小鼠相似,但降低肝脏铁蛋白亚单位水平和肝脏非血红素铁浓度的能力明显减弱。这种损伤的肝脏反应即使在限制膳食铁的情况下也能观察到。

在人和小鼠肝癌细胞系中,稳定缺氧诱导因子(HIF)的化学物质,包括去铁胺、氯化钴和二甲氧甘氨酸,都能提高NCOA4 mRNA的表达。这种NCOA4 mRNA的诱导发生在3小时内,先于NCOA4蛋白的升高,并在HIF-1a和HIF-2a双重敲除的情况下减弱。

综上所述,本研究首次展示了NCOA4在失血后促进肝脏铁动员方面的作用,以及HIF调节肝源性细胞中NCOA4的表达。鉴于调节HIF稳定性的脯氨酸羟化酶是氧和铁依赖性酶,本研究发现提出一种新的机制,即缺氧和缺铁可能通过调节NCOA4的表达来影响铁的体内平衡。

原始出处:

Xiuqi Li,et al. NCOA4 is Regulated by HIF and Mediates Mobilization of Murine Hepatic Iron Stores After Blood Loss. Blood. July 13,2020.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1699603, encodeId=d362169960322, content=<a href='/topic/show?id=15a24951c2' target=_blank style='color:#2F92EE;'>#COA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4951, encryptionId=15a24951c2, topicName=COA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=224929955832, createdName=circumcision, createdTime=Wed Jan 06 23:11:58 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1814970, encodeId=221118149e0ee, content=<a href='/topic/show?id=359e965323a' target=_blank style='color:#2F92EE;'>#铁储备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96532, encryptionId=359e965323a, topicName=铁储备)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b3e473, createdName=pyaili, createdTime=Wed May 26 00:11:58 CST 2021, time=2021-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805439, encodeId=475a8054392e, content=z, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ms 内分泌科张, createdTime=Fri Jul 31 20:51:23 CST 2020, time=2020-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804919, encodeId=3488804919d8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ms 内分泌科张, createdTime=Tue Jul 28 18:50:30 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522672, encodeId=ad4e15226e280, content=<a href='/topic/show?id=4c364430828' target=_blank style='color:#2F92EE;'>#失血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44308, encryptionId=4c364430828, topicName=失血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6c011466504, createdName=daviiliu, createdTime=Fri Jul 24 09:11:58 CST 2020, time=2020-07-24, status=1, ipAttribution=)]
    2021-01-06 circumcision
  2. [GetPortalCommentsPageByObjectIdResponse(id=1699603, encodeId=d362169960322, content=<a href='/topic/show?id=15a24951c2' target=_blank style='color:#2F92EE;'>#COA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4951, encryptionId=15a24951c2, topicName=COA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=224929955832, createdName=circumcision, createdTime=Wed Jan 06 23:11:58 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1814970, encodeId=221118149e0ee, content=<a href='/topic/show?id=359e965323a' target=_blank style='color:#2F92EE;'>#铁储备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96532, encryptionId=359e965323a, topicName=铁储备)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b3e473, createdName=pyaili, createdTime=Wed May 26 00:11:58 CST 2021, time=2021-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805439, encodeId=475a8054392e, content=z, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ms 内分泌科张, createdTime=Fri Jul 31 20:51:23 CST 2020, time=2020-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804919, encodeId=3488804919d8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ms 内分泌科张, createdTime=Tue Jul 28 18:50:30 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522672, encodeId=ad4e15226e280, content=<a href='/topic/show?id=4c364430828' target=_blank style='color:#2F92EE;'>#失血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44308, encryptionId=4c364430828, topicName=失血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6c011466504, createdName=daviiliu, createdTime=Fri Jul 24 09:11:58 CST 2020, time=2020-07-24, status=1, ipAttribution=)]
    2021-05-26 pyaili
  3. [GetPortalCommentsPageByObjectIdResponse(id=1699603, encodeId=d362169960322, content=<a href='/topic/show?id=15a24951c2' target=_blank style='color:#2F92EE;'>#COA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4951, encryptionId=15a24951c2, topicName=COA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=224929955832, createdName=circumcision, createdTime=Wed Jan 06 23:11:58 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1814970, encodeId=221118149e0ee, content=<a href='/topic/show?id=359e965323a' target=_blank style='color:#2F92EE;'>#铁储备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96532, encryptionId=359e965323a, topicName=铁储备)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b3e473, createdName=pyaili, createdTime=Wed May 26 00:11:58 CST 2021, time=2021-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805439, encodeId=475a8054392e, content=z, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ms 内分泌科张, createdTime=Fri Jul 31 20:51:23 CST 2020, time=2020-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804919, encodeId=3488804919d8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ms 内分泌科张, createdTime=Tue Jul 28 18:50:30 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522672, encodeId=ad4e15226e280, content=<a href='/topic/show?id=4c364430828' target=_blank style='color:#2F92EE;'>#失血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44308, encryptionId=4c364430828, topicName=失血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6c011466504, createdName=daviiliu, createdTime=Fri Jul 24 09:11:58 CST 2020, time=2020-07-24, status=1, ipAttribution=)]
    2020-07-31 ms 内分泌科张

    z

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1699603, encodeId=d362169960322, content=<a href='/topic/show?id=15a24951c2' target=_blank style='color:#2F92EE;'>#COA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4951, encryptionId=15a24951c2, topicName=COA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=224929955832, createdName=circumcision, createdTime=Wed Jan 06 23:11:58 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1814970, encodeId=221118149e0ee, content=<a href='/topic/show?id=359e965323a' target=_blank style='color:#2F92EE;'>#铁储备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96532, encryptionId=359e965323a, topicName=铁储备)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b3e473, createdName=pyaili, createdTime=Wed May 26 00:11:58 CST 2021, time=2021-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805439, encodeId=475a8054392e, content=z, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ms 内分泌科张, createdTime=Fri Jul 31 20:51:23 CST 2020, time=2020-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804919, encodeId=3488804919d8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ms 内分泌科张, createdTime=Tue Jul 28 18:50:30 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522672, encodeId=ad4e15226e280, content=<a href='/topic/show?id=4c364430828' target=_blank style='color:#2F92EE;'>#失血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44308, encryptionId=4c364430828, topicName=失血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6c011466504, createdName=daviiliu, createdTime=Fri Jul 24 09:11:58 CST 2020, time=2020-07-24, status=1, ipAttribution=)]
    2020-07-28 ms 内分泌科张

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1699603, encodeId=d362169960322, content=<a href='/topic/show?id=15a24951c2' target=_blank style='color:#2F92EE;'>#COA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4951, encryptionId=15a24951c2, topicName=COA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=224929955832, createdName=circumcision, createdTime=Wed Jan 06 23:11:58 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1814970, encodeId=221118149e0ee, content=<a href='/topic/show?id=359e965323a' target=_blank style='color:#2F92EE;'>#铁储备#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96532, encryptionId=359e965323a, topicName=铁储备)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b3e473, createdName=pyaili, createdTime=Wed May 26 00:11:58 CST 2021, time=2021-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805439, encodeId=475a8054392e, content=z, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ms 内分泌科张, createdTime=Fri Jul 31 20:51:23 CST 2020, time=2020-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804919, encodeId=3488804919d8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201214/b3170121d995432ea306ae3a7809cc05/2cfb236f361b4d3c80ef8fdef4301832.jpg, createdBy=8ad35400531, createdName=ms 内分泌科张, createdTime=Tue Jul 28 18:50:30 CST 2020, time=2020-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522672, encodeId=ad4e15226e280, content=<a href='/topic/show?id=4c364430828' target=_blank style='color:#2F92EE;'>#失血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44308, encryptionId=4c364430828, topicName=失血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6c011466504, createdName=daviiliu, createdTime=Fri Jul 24 09:11:58 CST 2020, time=2020-07-24, status=1, ipAttribution=)]
    2020-07-24 daviiliu

相关资讯

FDA批准Reblozyl治疗骨髓增生异常综合症相关的贫血

百时美施贵宝公司(Bristol Myers Squibb)近日宣布,FDA已扩大Reblozyl(luspatercept-aamt)的适应症范围。

J Periodontol:牙周炎可引起炎症性贫血

尽管白细胞增多症是严重牙周炎的常见特征,但关于牙周炎中红细胞计数的证据较少,这表明可能出现贫血趋势。本研究旨在调查牙周炎与循环白细胞,红细胞和血小板之间的关联。

《全国非透析慢性肾脏病患者贫血风险白皮书》蓄势待发

2020年7月4日,由中关村肾病血液净化创新联盟发起的“INSIGHT-全国非透析慢性肾脏病患者贫血风险调研项目”通过网络联线的方式如期进行了启动并进行了第一次专家讨论。

Blood:可抑制血小板吞噬作用的抗体,或可治疗ITP

红细胞抗体诱导性贫血并不是预测ITP小鼠模型治疗成功的抗体的充分条件。 体外成功阻断血小板吞噬的红细胞特异性抗体可改善ITP小鼠的ITP症状。

Blood:疟原虫在人红细胞中发育、影响宿主红细胞生成的机制

恶性疟原虫性寄生虫可在人成红细胞中充分发育;配子细胞和寄生虫衍生的细胞外囊泡可延缓红细胞生成,从而使寄生在有核细胞中的配子细胞有充足的时间发育完全。

日本厚生劳动省批准Vadadustat治疗慢性肾病引起的贫血

生物制药公司Akebia Therapeutics今日宣布,日本厚生劳动省已批准缺氧诱导因子脯氨酰羟化酶抑制剂vadadustat用于治疗慢性肾脏疾病(CKD)引起的贫血。