Clin Chem:直接基质衍生化联合LC-MS/MS对神经内分泌肿瘤患者富血小板血浆吲哚标记物的定量分析

2019-12-23 MedSci MedSci原创

目前,通过单独测量一些吲哚标记物以支持对神经内分泌肿瘤患者的诊断和随访。

目前,通过单独测量一些吲哚标记物以支持对神经内分泌肿瘤患者的诊断和随访。在此,研究人员开发了一种灵敏的质谱方法,可以同时测定富血小板血浆中所有与色氨酸相关的吲哚(色氨酸、5-羟色胺、5-羟吲哚乙酸)。采用直接-矩阵衍生化方法使吲哚类化合物的化学性质趋于一致,提高了分析的灵敏度和特异性。

在常温下,用丙酸酐直接在富血小板血浆中进行原位衍生化。将衍生吲哚在线固相萃取,洗脱到分析柱中进行分离,然后进行质谱检测。同时,该方法已根据国际准则进行了验证。本研究从68名健康个体和40名净患者的血浆样本中分析了富含血小板的色氨酸、5-羟色胺、5-羟吲哚乙酸。

研究结果显示,该方法可在8.5分钟内重现定量相关吲哚,包括在线样品清除。在3种不同浓度下,测定结果的内部和内部不精确性分别为2.0% - 12%1.9% - 13%。定量的限制足以测量所有4种吲哚的内源性浓度。健康个体和净患者的5-羟色胺、血清素和5-羟吲哚乙酸浓度不同,但色氨酸浓度相同。

研究结果表明,直接矩阵衍生化联合LC-MS/MS是同时定量富血小板血浆中所有色氨酸相关吲哚的有力工具。同时测定相关吲哚改善了网的生化特性和随访。

原始出处:

Martijn van Faassen, Grytsje Bouma, Quantitative Profiling of Platelet-Rich Plasma Indole Markers by Direct-Matrix Derivatization Combined with LC-MS/MS in Patients with Neuroendocrine Tumors

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    2020-01-16 gwc392
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  5. 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    2020-06-26 wjywjy
  8. 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