纤维化性间质性肺病患者住院或门诊肺康复治疗后的生存率-多中心回顾性队列研究

2021-09-15 小文子 MedSci原创

患者6分钟步行距离(6MWD)的改善是否与更高的生存率相关？

肺康复治疗对纤维化性间质性肺疾病（ILD）患者生存率的影响尚不清楚,患者6分钟步行距离(6MWD)的改善是否与更高的生存率相关？近日，发表在呼吸领域权威杂志Thorax的一篇文章探索了两者之间的关系。

本研究采用国际回顾性队列研究，纳入5个国家12家研究中心进行住院或门诊肺康复的纤维化性间质性肺病患者。使用多变量模型分析6分钟步行距离的变化与死亡时间或者肺移植时间之间的相关性。

研究最终纳入701例纤维化性 ILD患者（445例男性和256例女性）。196例住院患者和505例门诊患者的平均年龄（mean±SD）分别为70 ± 11岁和69 ± 12岁。住院患者6MWD基线/变化为262 ± 128/55 ± 83m，门诊患者为358 ± 125/34 ± 65m。住院患者(HR=0.94, 95%CI [0.91-0.97], p < 0.001)和门诊患者(HR=0.97, 95%CI [0.95-1.00], p = 0.042)肺康复期间6MWD 改善与死亡率和肺移植风险降低有关。参与80%以上门诊肺康复计划的患者能够降低33%的死亡风险(95%CI 0.49%-0.92%)。

纤维化性 ILD患者在肺康复期间体能状况有所改善，生存率明显高于未改善者。未来需要在随机对照试验中证实临床实践效果，为进一步提高纤维化性 ILD 患者肺康复的可用性而做出努力。

原文出处：

Guler SA, Hur SA, Stickland MK, et al Survival after inpatient or outpatient pulmonary rehabilitation in patients with fibrotic interstitial lung disease: a multicentre retrospective cohort study, Thorax, 2021. http://dx.doi.org/10.1136/thoraxjnl-2021-217361

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2021-10-01 luoxiaog

#多中心#

29 0
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2022-05-16 zjshifan_98647306

#间质性#

37 0
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2022-02-21 yangjxjc

#肺康复#

45 0
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2022-06-07 amy0559

#肺病#

30 0
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2022-07-07 12498a49m72暂无昵称

#肺康复治疗#

28 0
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2021-09-16 guoyibin

#生存率#

28 0
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2021-09-15 ms4000000069838862

很不错

61 0
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2021-09-15 仁术2021

不错学习了

48 0
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2021-09-15 学医无涯

学习一下

58 0

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