J Biomed Mater Res A:新型水凝胶的机械和成骨性能

2018-11-17 MedSci MedSci原创

由于机械性能差,用于生物医学应用的水凝胶仅限于骨组织工程。具有强度和弹性特征的韧性水凝胶受到广泛关注,但其应用受到水凝胶降解的限制。本研究介绍了一种增强水凝胶机械性能同时确保其降解的方法。羧基葡聚糖(Dex)通过聚(ε-己内酯)(PCL)进行接枝修饰,然后通过聚乙二醇400(PEG400)交联,得到在DMSO中具有共价交联单元的凝胶。将凝胶在H2O中进行溶剂置换以诱导PCL的疏水缔合以形成非共价交

由于机械性能差,用于生物医学应用的水凝胶仅限于骨组织工程。具有强度和弹性特征的韧性水凝胶受到广泛关注,但其应用受到水凝胶降解的限制。本研究介绍了一种增强水凝胶机械性能同时确保其降解的方法。

羧基葡聚糖(Dex)通过聚(ε-己内酯)(PCL)进行接枝修饰,然后通过聚乙二醇400(PEG400)交联,得到在DMSO中具有共价交联单元的凝胶。将凝胶在H2O中进行溶剂置换以诱导PCL的疏水缔合以形成非共价交联单元。

结果显示,Dex-g-PCL水凝胶的最大应变为90%±6%,相应的应力为2.7±0.2MPa,与葡聚糖水凝胶相比明显增强(最大应变65%± 5%,相应应力为0.225±0.06 MPa)。大多数水凝胶在体内12 w后降解,仅有少量残留物。脂肪来源的干细胞(ASCs)在接种于水凝胶中14天后增殖良好。

综上所述,体外和体内血管生成以及体外成骨说明了携带ASCs的Dex-g-PCL水凝胶在血管化骨组织工程中的潜力。

原始出处:

Cai L, Li J, et al., Dextran-based hydrogel with enhanced mechanical performance via covalent and non-covalent cross-linking units carrying adipose derived stem cells towards vascularized bone tissue engineering. J Biomed Mater Res A. 2018 Nov 15. doi: 10.1002/jbm.a.36580.

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    2019-06-18 sunylz
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    2018-11-19 tastas
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    2018-11-19 zhaojie88
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    2018-11-19 lishizhe
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    2018-11-19 hb2008ye