IBD:炎症性肠病亚临床骶髂关节炎的患病率和临床相关性分析

2019-05-07 不详 MedSci原创

骶髂关节炎是一种与强直性脊柱炎(AS)相关的炎性关节疾病,在患有炎症性肠病(IBD)的患者中经常出现,但可能未被明确诊断。本研究的目的是评估IBD中骶髂关节炎的患病率,并确定IBD临床特征与骶髂关节炎之间的关联。

背景
骶髂关节炎是一种与强直性脊柱炎(AS)相关的炎性关节疾病,在患有炎症性肠病(IBD)的患者中经常出现,但可能未被明确诊断。本研究的目的是评估IBD中骶髂关节炎的患病率,并确定IBD临床特征与骶髂关节炎之间的关联。

方法
研究人员对所有确诊有IBD的患者行腹部-盆腔计算机断层扫描(CT)以评估骶髂关节炎的存在。两名盲法读者使用标准化模型,其中强直或侵蚀评分> 3表示骶髂关节炎。人口统计学,IBD特征,临床活动(Harvey Bradshaw Index> 4,Mayo> 2),内镜活动(克罗恩病的简单内镜评分> 4 / Mayo subscore> 1),以及关节炎/肠外表现(EIMS) )均被记录下来。

结果
本项研究共纳入316名患者(50%为男性; 74%为克罗恩病[CD])。计算机断层扫描评分确定49例(16%)患有骶髂关节炎。放射科医生报告其中33%患有骶髂关节炎。5名患者曾去过脊柱炎诊所。49人中有33人进行了腹部X光检查。超过5个骶髂关节糜烂与放射科医师报告的骶髂关节炎有关(P <0.0001)。CD和溃疡性结肠炎的患病率无差异。骶髂关节炎与男性性行为有关(63.3%vs 47.9%;优势比[OR],1.8; P = 0.04),已知关节炎(41%vs 12%; OR,4.7; P <0.0001),疼痛为IBD症状( 77.7% vs 56.9%; P.= 0.03)和CD炎症表型(P = 0.01)有关。

结论
骶髂关节炎在IBD中与男性,关节炎和炎症性CD相关。

原始出处:

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    2019-05-09 bnurmamat
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    2019-05-09 lmm397
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    2019-05-07 jingjing

    大家一般关心疾病,但是亚临床更重要,这是疾病防控方向的前移,各类疾病都是这样。如亚临床甲减,亚临床心肌损伤,亚临床心衰等

    0

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