Stroke:睡眠呼吸对缺血性卒中患者功能预后的影响

2020-06-10 MedSci原创 MedSci原创

在缺血性卒中早期通过CPC分析评估的SDB可以预测3个月时的严重和长期功能障碍。使用动态心电图监测进行的CPC分析可以帮助预测急性缺血性卒中患者的功能损害。

心肺耦合(CPC)分析是评估睡眠呼吸障碍(SDB)的一种容易评估方法。然而,它对急性缺血性卒中患者的预后影响有待进一步研究。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员对处于非心脏栓塞性缺血性卒中早期阶段的患者进行动态心电图监测并开展CPC分析,以探究SDB对3个月随访中功能损害的预后影响。 来自多中心、前瞻性、所有人群的615名急性非心脏栓塞性缺血性卒中患者在卒中发作30天内接受了动态心电图监测,并进行了CPC分析,且通过睡眠期间窄带耦合来定义SDB。研究人员采用改良的Rankin量表调查了3个月时SDB与功能障碍之间的关联。

615名患者中的191名(31.1%)存在窄带耦合(平均年龄64.5±12.6岁)。窄带组在为期3个月的随访中发生严重功能障碍(改良Rankin量表评分>2;45.5% vs. 12.9%,P<0.001)和持续残疾(Δ改良Rankin量表评分≤0; 53.9% vs. 39.8%,P<0.001)的几率更高。在多变量分析中,窄带耦合是3个月严重和持续性功能障碍风险更高的独立预测因子(比值比为3.98[95%CI为2.34-6.78];P<0.001;比值比为1.81 [95%CI为1.23-2.66];P<0.001)。在对157名患者进行倾向得分匹配分析后,结果保持一致(C统计量=0.770)。

由此可见,在缺血性卒中早期通过CPC分析评估的SDB可以预测3个月时的严重和长期功能障碍。使用动态心电图监测进行的CPC分析可以帮助预测急性缺血性卒中患者的功能损害。

原始出处:

Dong Oh Kang,et al.Impact of Sleep-Disordered Breathing on Functional Outcomes in Ischemic Stroke A Cardiopulmonary Coupling Analysis.stroke.2020.https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.028730

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    2020-06-11 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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背景:与男性相比,女性脑卒中后的预后较差,但在静脉溶栓(IVT)治疗的患者中,女性似乎收益更大。除了性别差异,年龄也有可能影响功能预后。在IVT治疗的患者中,年龄与性别对患者的功能预后的相互作用是很复杂的。本研究应用一个大型的多中心欧洲队列,此队列反映急性卒中治疗的日常临床实践,旨在比较不同年龄层的男性和女性IVT患者的预后。方法: 从12个欧洲三级医院获得IVT登记的数据。主要结果是功能预后不良

Stroke:替罗非班提高了血管内取栓治疗的AIS患者功能预后!

在接受了ET治疗的AIS患者中,替罗非班与较高的sICH无关,这似乎导致了较低的死亡和更好的长期功能独立性几率。但是替罗非班预防早期再闭塞的疗效、潜在机制及其最佳治疗方案需要进一步的研究来予以确定。

Stroke:轻型卒中的血管内治疗,何去何从?

在多项大血管闭塞性(large vessel occlusion,LVO) 急性缺血性卒中的 RCT 研究中,血管内血栓切除术(Endovascular thrombectomy,EVT)和最佳内科治疗相比能够提高再通率和临床预后。