Diabetes Obes Metab:2型糖尿病患者DPP-4抑制剂治疗与COVID-19

2020-05-29 MedSci原创 MedSci原创

总而言之,研究人员没有发现DPP-4i可能影响COVID-19住院的证据。

由于其他冠状病毒通过与二肽基肽酶-4(DPP-4)结合而进入细胞,因此推测DPP-4抑制剂(DPP-4i)可能具有抗SARS-CoV-2的活性。近日,代谢内分泌疾病领域权威杂志Diabetes Obesity & Metabolism上发表了一篇研究文章,在缺乏临床试验结果的情况下,研究人员分析了流行病学数据以支持或放弃这种假设。

研究人员检索了在意大利因COVID-19住院的2型糖尿病(T2D)患者中使用DPP-4i的信息。作为对照,研究人员检索了同一地区匹配的T2D患者DPP-4i使用情况。

在403例COVID-19住院患者中,有85例患有T2D。患有COVID-19的T2D患者(10.6%)和该地区的14857例匹配患者(8.8%)或本地门诊的793例匹配患者(15.4%)、8284例匹配的因其他原因住院的患者(8.5%)使用DPP-4i的几率相似,71例因COVID-19肺炎住院的患者(11.3%)与351例其他原因性肺炎匹配患者(10.3%)进行比较使用DPP-4i的几率也相似。伴有COVID-19的T2D患者接受DPP-4i治疗后的疾病结局与未接受DIP-4i治疗的患者相似。

总而言之,研究人员没有发现DPP-4i可能影响COVID-19住院的证据。

原始出处:

Gian Paolo Fadini.et al.Exposure to DPP ‐4 inhibitors and COVID ‐19 among people with type 2 diabetes. A case–control study.Diabetes Obesity & Metabolism.2020.https://publons.com/publon/10.1111/dom.14097

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    2020-08-16 guojianrong
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    2020-06-27 一闲
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  5. 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1888148, encodeId=5d1d188814825, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sun Aug 16 16:44:03 CST 2020, time=2020-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1639473, encodeId=6b7116394e3c2, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, 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encodeId=da9413e4127bd, content=<a href='/topic/show?id=dad4621545' target=_blank style='color:#2F92EE;'>#DPP-4抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6215, encryptionId=dad4621545, topicName=DPP-4抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8d7373, createdName=ewsr1, createdTime=Sat May 30 23:44:03 CST 2020, time=2020-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383627, encodeId=4a74138362e4b, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Sat May 30 23:44:03 CST 2020, time=2020-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401964, encodeId=31281401964da, content=<a href='/topic/show?id=7ff0621125' target=_blank style='color:#2F92EE;'>#DPP-4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6211, encryptionId=7ff0621125, topicName=DPP-4)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJmFzSicR3biaepTGaMtOl8hS8SjNQ92YP4GmFUlefPkcPnZJWBsHM057ogFrQEPrgdTgPrlxG70KYA/132, createdBy=eeb42370314, createdName=gaoxiaoe, createdTime=Sat May 30 23:44:03 CST 2020, time=2020-05-30, status=1, ipAttribution=)]
    2021-03-04 jklm09
  7. 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    2020-05-30 gaoxiaoe

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四川大学华西医院眼科的Li H近日在Int Immunopharmacol杂志上发表了一篇重要的工作,他们研究发现商业化的DPP-4抑制剂linagliptin,在视网膜血管内皮细胞中具有保护作用。

DPP-4抑制剂临床应用专家指导建议解读:CDS2019

在11月20日-23日举办的中华医学会糖尿病学分会第二十三次全国学术会议(CDS 2019)年会上,解放军总医院第一医学中心内分泌科的窦京涛教授,针对DPP-4抑制剂临床应用专家指导建议进行了详细解读,主要归纳为五大类问题,在此小编整理精彩内容与大家分享。一、临床地位及基本信息1.DPP-4抑制剂的降糖机制是什么?DPP-4抑制剂的降糖机制:以葡萄糖浓度依赖的方式促进胰岛素分泌、抑制胰高血糖素分泌

Diabetes Care:“调解官”二甲双胍能改善DPP-4抑制剂对心血管的影响?

二甲双胍首选用于单纯饮食控制及体育锻炼治疗无效的2型糖尿病,特别是肥胖的2型糖尿病患者。2017年12月,发表在《Diabetes Care》的一项由美国科学家进行的meta分析,考察了二甲双胍的使用对调和DPP-4抑制剂对心血管结局有何影响。

DPP-4抑制剂——二联用药中的换药优选

DDP-4抑制剂——二联用药中的换药优选

Diabetes Care:二甲双胍或可调节DPP-4抑制剂对心血管结局的影响。

本研究的目的是探索普遍使用的二甲双胍对二肽基肽酶4抑制剂(DPP-4i)对心血管影响的潜在调节作用。

DPP-4抑制剂临床应用专家共识

传统降糖药物在糖尿病的治疗中发挥着巨大的作用,但是由于糖尿病发病机制的复杂性,传统降糖药物仍然不能满足临床需要。因此,开发具有新作用机制的抗糖尿病药物具有十分重要的意义。 近年涌现出一些与传统降糖药物作用机制迥异的新药,二肽基肽酶-4 (DPP-4)抑制剂即是其中之一、目前已问世的 DPP-4抑制剂有几十种 ,国内上市的有西格列汀、维格列汀、沙格列汀、阿格列汀和利格列汀、 这些药物被统称为格列汀(