还在带眼镜防蓝光伤眼,那脑和衰老呢?研究发现,蓝光可改变代谢使神经变性,加速衰老!

2022-09-04 MedSci原创 MedSci原创

Front. Aging:慢性蓝光通过损害能量代谢和神经递质水平导致果蝇加速衰老

以高能短波光为特征的蓝光(BL)作为对人类健康的潜在危害引起了人们的兴趣。BL在发光二极管(LED)等人工照明中很常见,人类越来越多地接触到这些。越来越多的证据表明,BL有可能损害人眼,导致从青光眼到视网膜变性和年龄相关性黄斑病的疾病;然而,人们对损伤的机制知之甚少。

另一方面,最近在Drosophila melanogaster上的研究表明,在整个生命周期中长期暴露于BL会导致加速衰老,表现为寿命缩短和脑神经变性,这表明BL可以损害不专门用于光感知的细胞和组织。在生理水平上,BL暴露会损害果蝇的线粒体功能,但这些影响的代谢基础尚未得到研究。

因此,本研究旨在研究慢性BL对眼头代谢途径的影响(eya2)突变的果蝇,以便专注于视网膜外组织。

通过对数等级测试比较的死亡率曲线显示,与DD对照组相比,果蝇的存活率与BL中增加的天数成比例显着降低。在BL中保持10天的果蝇的寿命略有但显著减少,并且在恒定BL中保持14天的果蝇的寿命减少得更为显著,但没有果蝇在BL暴露期间死亡。然而,在BL中饲养16天的果蝇中,有些在BL暴露期间和之后不久死亡,而另一些则在DD中存活并继续生活,表明该队列由具有可逆和不可逆BL损伤的果蝇组成。

研究人员接下来评估脑神经变性。在BL中保存10d的果蝇显示出类似于DD控制的可忽略不计的空泡化。然而,与年龄匹配的DD对照相比,在BL暴露14和16天后检测到脑空泡的显着增加。研究人员随后研究了BL在这两个时间点对代谢组学谱的影响,以深入了解与脑损伤发作相关的代谢物变化。

研究人员使用LC-MS和GC-MS比较了在恒定BL或恒定黑暗中保持10或14天的果蝇的代谢组学谱。数据分析显示,几种代谢物的水平发生了显著变化,这表明关键的细胞途径在BL暴露的果蝇中受到影响。特别是,在BL中饲养14天的果蝇头部观察到显着的代谢重排,包括琥珀酸盐水平高度升高但丙酮酸盐和柠檬酸盐水平降低,表明能量产生受损。

这些果蝇也显示出神经变性的发作,分析检测到几种神经递质的水平显著降低,包括谷氨酸和γ-氨基丁酸(GABA),这表明BL破坏了大脑稳态。

综上所述,自然光是生命所必需的,但长时间暴露于高含量蓝色波长的人造光,是人类健康日益关注的问题,特别是在视网膜病理学方面。然而,关于模式生物C. elegansD. melanogaster证明不专门用于光感知的细胞和组织,如大脑,可以在长时间保持在BL中的果蝇中受损。本研究研究了慢性BL对具有遗传消融眼睛的果蝇头部代谢途径的影响,以关注视网膜外组织。代谢组学分析揭示了几种代谢物水平的变化,这表明这些果蝇的能量产生和其他细胞途径发生了显着变化。特别是,在BL中保持14天的果蝇头部观察到显着的代谢重排。这些果蝇表现出神经变性,与加速衰老一致。因此,研究结果可能会提供对最初保护果蝇生理的机理作用的见解,以及可能在长时间暴露于BL时损害果蝇细胞的代谢损伤。

 

原文来源:

Jun Yang, et al. Chronic blue light leads to accelerated aging in Drosophila by impairing energy metabolism and neurotransmitter levels. Front. Aging, 31 August 2022. Sec. Genetics, Genomics and Epigenomics of Aging
https://doi.org/10.3389/fragi.2022.983373

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    2022-09-05 huangdf
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    2022-09-05 小小医者

    #蓝光#的危害很大,目前很多高档的电子产品,都已过滤了蓝光了。#衰老##视力#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1753676, encodeId=5bb21e536764e, content=<a href='/topic/show?id=6a57e33772b' target=_blank style='color:#2F92EE;'>#研究发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73377, encryptionId=6a57e33772b, topicName=研究发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1736602208, createdName=hanhaisha2020, createdTime=Thu Mar 02 08:48:03 CST 2023, time=2023-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463825, encodeId=ab071463825ea, content=<a href='/topic/show?id=7d27381288e' target=_blank style='color:#2F92EE;'>#变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38128, encryptionId=7d27381288e, topicName=变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f69f6545041, createdName=huangdf, createdTime=Mon Sep 05 05:48:03 CST 2022, time=2022-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560428, encodeId=8a5e156042820, content=<a href='/topic/show?id=4ff1e294238' target=_blank style='color:#2F92EE;'>#眼镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72942, encryptionId=4ff1e294238, topicName=眼镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=508115130308, createdName=zhangfenasdf, createdTime=Mon Sep 05 05:48:03 CST 2022, time=2022-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566437, encodeId=b1b9156643ec0, content=<a href='/topic/show?id=4ff1e294238' target=_blank style='color:#2F92EE;'>#眼镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72942, encryptionId=4ff1e294238, topicName=眼镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=508115130308, createdName=zhangfenasdf, createdTime=Mon Sep 05 05:48:03 CST 2022, time=2022-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1590533, encodeId=2f66159053334, content=<a href='/topic/show?id=d785e42454f' target=_blank style='color:#2F92EE;'>#神经变性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74245, encryptionId=d785e42454f, topicName=神经变性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d72417807199, createdName=mfx805, createdTime=Mon Sep 05 05:48:03 CST 2022, time=2022-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1243224, encodeId=10161243224ef, content=<a href='/topic/show?id=8878883527c' target=_blank style='color:#2F92EE;'>#蓝光#</a>的危害很大,目前很多高档的电子产品,都已过滤了蓝光了。<a href='/topic/show?id=4c239032154' target=_blank style='color:#2F92EE;'>#衰老#</a><a href='/topic/show?id=4ae49066e76' target=_blank style='color:#2F92EE;'>#视力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88352, encryptionId=8878883527c, topicName=蓝光), TopicDto(id=90321, encryptionId=4c239032154, topicName=衰老), TopicDto(id=90667, encryptionId=4ae49066e76, topicName=视力)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=小小医者, createdTime=Mon Sep 05 02:18:47 CST 2022, time=2022-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1243081, encodeId=c7081243081f5, content=电子产品真的改变世界, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200624/b7a6102cc78140bd8a43fc1f5fafb0d4/86325fa031bc4aff97a640f9ec2f8c4e.jpg, createdBy=92185393955, createdName=woolin, createdTime=Sun Sep 04 10:19:54 CST 2022, time=2022-09-04, status=1, ipAttribution=)]
    2022-09-04 woolin

    电子产品真的改变世界

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