J Oral Maxillofac Surg:预先使用布洛芬 第三磨牙拔除术后疼痛减轻

2019-05-20 王蕤 编译 中国医学论坛报今日口腔

土耳其一项研究表明,布洛芬的预先使用可使第三磨牙拔除术后第一个24小时内疼痛减轻且补救镇痛需求减少。该论文2019年4月24日在线发表于《口腔颌面外科学杂志》(J Oral Maxillofac Surg)。


土耳其一项研究表明,布洛芬的预先使用可使第三磨牙拔除术后第一个24小时内疼痛减轻且补救镇痛需求减少。该论文2019年4月24日在线发表于《口腔颌面外科学杂志》(J Oral Maxillofac Surg)。

该研究的目的是确定静脉注射布洛芬在下颌第三磨牙手术中是否具有先发性镇痛作用。研究者将75例患者随机分为3组:第1组术前60分钟接受静脉注射布洛芬,术后接受静脉注射安慰剂(100毫升生理盐水);第2组术前接受静脉注射安慰剂(100 ml生理盐水),术后60 min接受静脉注射布洛芬;第3组在手术前后60分钟接受静脉注射安慰剂(100 ml生理盐水)。术后疼痛在术后1小时、2小时、4小时、6小时、8小时、12小时和24小时以视觉模拟评分(VAS)记录。在术后第一个24小时内记录了对乙酰氨基酚摄入的总剂量。

与其他组相比,术前静脉注射布洛芬组术后镇痛效果更高(P<0.001)。与其他组相比,安慰剂组在第一个小时内接受了更多的补救镇痛。在手术后的第一个24小时内,第1组内施用的对乙酰氨基酚的平均剂量为640 mg,而第2组为1240 mg,第3组为1840  mg。(P <0.001)。

原始出处:

El-Rabbany M,et al.Surgical Management of Medication-Related Osteonecrosis of the Jaw Is Associated With Improved Disease Resolution: A Retrospective Cohort Study.J Oral Maxillofac Surg. 2019 Apr 9. pii: S0278-2391(19)30367-2. doi: 10.1016/j.joms.2019.03.040. [Epub ahead of print]

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    2019-09-11 小几洁
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