PLos One:NT-proBNP预测慢性心衰患者两年预后的价值

2019-03-30 xiangting MedSci原创

在慢性心衰患者中使用考虑到利尿钠肽的预测模型,应成为常规临床实践的标准。

根据指南,可以通过确定利尿钠肽的水平、NYHA分级和合并症来预测慢性心衰患者的预后。这项研究的目标是在慢性心衰患者中建立考虑到患者合并症、NYHA和NT-proBNP水平的预后评分。

共有1,088名射血分数降低(HFrEF)(LVEF<40%)和中等EF(HFmrEF)(LVEF 40-49%)的慢性心衰患者连续入组。将两年全因死亡率、心脏移植和/或LVAD植入定义为主要终点(EP)。EP的发生率为14.9%,并随着NYHA分级的升高而增加,即4.9%(NYHA I)、11.4%(NYHA II)和27.8%(NYHA III-IV)(p<0.001)。在NT-proBNP水平≤125ng/L、126-1000ng/L和>1000ng/L的患者中,EP的发生率分别为3%、10%和15-37%。NYHA和NT-proBNP的辨别能力分别为AUC 0.670(p<0.001)和AUC 0.722(p<0.001)。考虑到年龄大、晚期心衰(NYHA III+IV)、贫血、低钠血症、高尿酸血症和大剂量呋塞米(每日>40mg)的临床模型的预测值(AUC 0.773; p<0.001),在加入NT-proBNP水平后升高(AUC 0.790)。

在慢性心衰患者中使用考虑到利尿钠肽的预测模型,应成为常规临床实践的标准。它有助于更好地识别需要更强治疗的高危患者,例如心脏移植或LVAD植入。

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    2019-04-01 huiwelcome
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    2019-04-01 mjldent
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    2019-04-01 sunylz
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    2019-03-30 中医痴

    不错的,学习了,谢谢分享!

    0

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