IBD : 儿童炎症性肠病患者行肠外营养的血栓和感染风险

2019-03-05 不详 MedSci原创

营养不良在炎症性肠病(IBD)中很常见,需要及时和充分的营养补充。但住院的患者中存在活动性疾病,症状和/或肠功能改变阻碍了肠内营养的可行性。在这种情况下,使用肠胃外营养(PN)成为了主要治疗方案。本项研究的目标是(1)评估1997年至2012年间住院儿童IBD患者使用PN的频率,(2)确定院内血栓和PN相关感染的风险。

背景
营养不良在炎症性肠病(IBD)中很常见,需要及时和充分的营养补充。但住院的患者中存在活动性疾病,症状和/或肠功能改变阻碍了肠内营养的可行性。在这种情况下,使用肠外营养(PN)成为了主要治疗方案。本项研究的目标是(1)评估1997年至2012年间住院儿童IBD患者使用PN的频率,(2)确定院内血栓和PN相关感染的风险。

方法
研究人员对1997年至2012年间住院的儿科患者进行了横断面分析。使用儿童住院患者数据库(KID)来确定患有克罗恩病(CD)或溃疡性结肠炎(UC)的儿科患者(≤18岁), PN暴露的情况,主要观察结果包括血栓和感染的发生情况。

结果
在30914例IBD住院治疗中,3732例(12%)使用肠外营养。3%的PN患者出现血栓性并发症,5.5%的患者出现感染性并发症。多变量分析显示PN是血栓(优势比[OR],4.3; 95%置信区间[CI],3.2-5.6)和感染(OR,3.8; 95%CI,3.1-4.6)的独立危险因素。手术是暴露于PN的住院期间血栓(OR,2.0; 95%CI,1.4-2.7)和感染(OR,2.5; 95%CI,2.0-3.1)的独立危险因素。

结论
住院的儿科IBD患者,特别是接受PN的手术患者易患血栓形成和感染。

原始出处:

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    2019-03-07 bnurmamat
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