AJG: 美国的私人门诊内镜中心的幽门螺杆菌阳性的消化性溃疡患病率明显降低

2020-01-27 不详 MedSci原创

在过去的几十年中,胃溃疡和十二指肠溃疡的患病率以及幽门螺杆菌感染率已明显下降。我们假设幽门螺杆菌患病率下降已降低了幽门螺杆菌阳性胃溃疡和十二指肠溃疡的比例。本研究旨在在以社区为基础的内窥镜检查中心接受食管胃十二指肠镜检查的人群中检验这一假设。

目标:
在过去的几十年中,溃疡和十二指肠溃疡的患病率以及幽门螺杆菌感染率已明显下降。我们假设幽门螺杆菌患病率下降已降低了幽门螺杆菌阳性溃疡和十二指肠溃疡的比例。本研究旨在在以社区为基础的内窥镜检查中心接受食管胃十二指肠镜检查的人群中检验这一假设。

方法:
本项研究共纳入1289641例食管胃十二指肠镜检查患者的临床数据,研究人员研究分析了患者年龄,性别,种族,幽门螺杆菌状况,诊断年份和溃疡类型分层的消化性溃疡的患病率。使用多元逻辑回归分析分析了多个预测变量对胃溃疡和十二指肠溃疡发生的联合影响。

结果:
在2009年至2018年之间,幽门螺杆菌感染的普遍发生率从11%显着下降到9%。这种下降伴随着幽门螺杆菌阳性胃溃疡的比例从17%下降到14%,而幽门螺杆菌阳性十二指肠溃疡的比例从25%下降到21%。如今,所有溃疡患者中只有17%患有幽门螺杆菌。与总人口相比,西班牙裔人中幽门螺杆菌的患病率高2.6倍,东亚人中幽门螺杆菌的患病率高3.2倍。在东亚和西班牙裔中,幽门螺杆菌阳性胃溃疡的比例分别为37%和35%。

讨论:
幽门螺杆菌感染继续在普通人群中下降。即使在溃疡患者中,也只有少数人感染幽门螺杆菌。

原始出处:

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    2020-07-05 kcb069
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    2020-05-10 minzju5052
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    2020-01-29 xinmeili
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