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ATVB：2型糖尿病与神经性压力反射敏感性降低独立相关

2020-03-20 MedSci原创 MedSci原创

2型糖尿病,神经性压力反射敏感性,降低,相关
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在这项以社区为基础的研究中，与葡萄糖代谢正常的受试者相比，50到75岁之间的HMR和T2D患者nBRS逐渐下降。

压力反射功能受损是心血管自主神经失调的早期指标。2型糖尿病(T2D)患者的压力反射敏感性(baroreflex sensitivity, BRS)有所下降，但对于那些具有高代谢风险(HMR、空腹血糖受损和代谢综合征)或明显T2D的患者，其神经BRS (nBRS)和BRS的机械成分是否发生了改变，目前尚不清楚。近日，心血管领域权威杂志Arteriosclerosis, Thrombosis, and Vascular Biology上发表了一篇研究文章，研究人员旨在通过社区为基础的观察性研究巴黎前瞻性研究III (PPS3)对此进行了探究。

在7626名年龄在50到75岁之间的成年人中，研究人员通过高精度颈动脉超声跟踪测量了受试者的静息nBRS(通过来自颈动脉扩张率和RR[两个连续的R波之间的时间间隔]的低频增益来估计)和机械性BRS。与正常糖代谢的受试者相比，研究人员通过多变量线性回归分析进行了量化了T2D或HMR与nBRS或机械性BRS之间的关系。

T2D患者有319例(61±6岁，男性占77%)，HMR患者1450例(60±6岁，男性占72%)，葡萄糖代谢正常者5857例(59±6岁，男性占57%)。调整混杂因素和中介因素后，与正常的葡萄糖代谢相比，HMR(β=−0.07(95%可信区间为0.12−0.01);P=0.029)和T2D(β=-0.18(95%可信区间为0.29−0.07);P=0.002)患者nBRS显著降低。亚组分析显示，仅在空腹血糖和代谢综合征同时受损的HMR患者中机械性BRS发生了显著的改变。

在这项以社区为基础的研究中，与葡萄糖代谢正常的受试者相比，50到75岁之间的HMR和T2D患者nBRS逐渐下降。

原始出处：

Domonkos Cseh.et al.Type 2 Diabetes Mellitus Is Independently Associated With Decreased Neural Baroreflex Sensitivity The Paris Prospective Study III.ATVB.2020.https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.314102

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    2021-02-17 12498cf9m35(暂无昵称)

    #压力反射敏感性#

    0

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    2020-09-07 hywen7326

    #神经性#

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    2020-04-07 gongliu

    #TVB#

    0

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    2020-03-21 ms5236388012055669

    #敏感性#

    0

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    2020-03-21 天地飞扬

    学习

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1957419, encodeId=f434195e41957, content=<a href='/topic/show?id=cd1136938be' target=_blank style='color:#2F92EE;'>#压力反射敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36938, encryptionId=cd1136938be, topicName=压力反射敏感性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Wed Feb 17 05:51:16 CST 2021, time=2021-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035454, encodeId=71222035454c2, content=<a href='/topic/show?id=d382e42956d' target=_blank style='color:#2F92EE;'>#神经性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74295, encryptionId=d382e42956d, topicName=神经性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=927d310, createdName=hywen7326, createdTime=Mon Sep 07 04:51:16 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977978, encodeId=d82919e797890, content=<a href='/topic/show?id=20411e958de' target=_blank style='color:#2F92EE;'>#TVB#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17958, encryptionId=20411e958de, topicName=TVB)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Tue Apr 07 06:51:16 CST 2020, time=2020-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388495, encodeId=541013884950e, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJnkE6UvGFfMS41qV0RicWvVTTeLMicqibeZH5GqO4YhNicyl1Y9jFhylIUBn9ntPYy9jhk5hrfic5cRYw/132, createdBy=5f822500020, createdName=ms5236388012055669, createdTime=Sat Mar 21 23:51:16 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=380813, encodeId=0049380813b4, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat Mar 21 20:03:57 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043027, encodeId=6463104302e2e, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Mar 20 11:51:16 CST 2020, time=2020-03-20, status=1, ipAttribution=)]
    2020-03-20 misszhang

    谢谢MedSci提供最新的资讯

    0