3763 例房颤消融分析:睡眠呼吸暂停增加复发风险,使用呼吸机可避免手术“白做”

2018-09-10 卢芳 中国循环杂志

对于睡觉打鼾,白日思睡的房颤患者,做了个射频消融手术却又复发房颤,怎么能尽可能不白做手术?

对于睡觉打鼾,白日思睡的房颤患者,做了个射频消融手术却又复发房颤,怎么能尽可能不白做手术?

这类睡觉打鼾,白日思睡的患者多患有阻塞性睡眠呼吸暂停,而近期一项Meta分析显示,给予这类患者持续气道正压通气治疗阻塞性睡眠呼吸暂停,会降低射频消融术后房颤复发风险。

如果合并阻塞性睡眠呼吸暂停,射频消融术后的房颤复发率高达35.2%,明显高于无阻塞性睡眠呼吸暂停的房颤患者(21.6%)。

但如果给你持续气道正压通气治疗阻塞性睡眠呼吸暂停,复发率则下降至23.6%,要比未治疗的房颤患者明显较低(37.5%),与无阻塞性睡眠呼吸暂停的房颤患者相似。

研究者介绍说,阻塞性睡眠呼吸暂停患者做做持续气道正压通气治疗,降低房颤复发风险,可能由于可改善心房重构,改善心房电传导,降低氧化应激,降低炎性水平,改善肾脏灌注等有关。

而且还有研究显示,好处是随着通气治疗时间的延长而增加的。

该研究共纳入7项研究共3763例房颤患者,其中合并睡眠呼吸暂停且给予持续气道正压通气治疗的房颤患者529例,未给予并睡眠呼吸暂停治疗睡眠呼吸暂停的房颤患者515例,以及无睡眠呼吸暂停的房颤患者2 719例。

原始出处:
程杰龙,肖源,詹碧鸣,等. 持续气道正压通气治疗阻塞性睡眠呼吸暂停对心房颤动射频消融术疗效影响的Meta分析. 中国循环杂志, 2018, 33: 781-786.

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    2018-09-12 Boyinsh
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    2018-09-10 医者仁心5538

    学习了

    0

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