Ocul Surf:短时间泪膜破裂的干眼症患者的角膜触觉和疼痛感研究

2018-08-22 cuiguizhong MedSci原创

日本北海道大学医学部和医学研究科眼科的Tagawa Y等人近日在Ocul Surf杂志发表一项重要工作,他们评估了短时间泪膜破裂干眼症(sBUT DE)患者的角膜触觉和疼痛感。

日本北海道大学医学部和医学研究科眼科的Tagawa Y等人近日在Ocul Surf杂志发表一项重要工作,他们评估了短时间泪膜破裂干眼症(sBUT DE)患者的角膜触觉和疼痛感。

该研究招募了60名患有sBUT DE的患者和来自日本的46名健康志愿者。他们使用Cochet-Bonnet角膜测量仪的改良方法评估了角膜触觉和疼痛感觉。

结果他们发现,sBUT DE患者的角膜疼痛敏感度(26.3±23.1mm)高于健康受试者(6.9±16.4mm),但角膜触觉感觉相似(分别为52.0±15.5mm和52.9±14.9mm)。在患有sBUT DE和角膜痛觉过敏(n = 22,36.7%)的患者中,疼痛敏感度定义为≥40mm(即健康受试者角膜疼痛敏感性的第95百分位数的截止值),发现主观疼痛评分与客观角膜疼痛感之间存在强烈的显着的相关性(R = 0.79)。然而,对于整个队列,他们发现,主观疼痛评分与客观角膜疼痛感之间存在微弱的正相关。

因此,他们认为,sBUT DE患者对角膜疼痛过敏,这表明角膜痛觉过敏部分地解释了sBUT DE患者的主观症状。

原文出处:

Tagawa, Y., et al., Corneal hyperalgesia in patients with short tear film break-up time dry eye. Ocul Surf, 2018.

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    2021-04-13 1025039950

    学到了!

    0

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    2018-10-13 清风拂面

    谢谢分享学习

    0

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    2018-08-24 snowpeakxu
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    2018-08-24 yeaweam
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    2018-08-22 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0