Hypertension:维生素D状态与老年人直立性低血压无关

2019-07-23 xing.T MedSci原创

总之,维生素D与老年人直立性低血压无显著相关性。

人们对调查体位性低血压患者维生素D状态很感兴趣。然而,研究很少,且结果不一致。近日,心血管权威杂志Hypertension上发表了一篇研究文章,该研究的目的是在大型全国代表性老年人群中使用可追溯的测量标准和准确评估的血压(BP)来调查与维生素D状态的相关性。

本研究使用了来自爱尔兰老年人纵向研究年龄>50岁的参与者。BP站立时的稳定性受损定义为收缩压持续下降≥20mmHg或舒张压下降≥10mmHg,直至静置后40秒(站立时BP稳定性受损)。研究人员还分析了在整个110秒站立时(OH110)收缩压持续下降≥20mmHg或舒张压下降≥10mmHg。维生素D分类为足够(≥50nmol/L)、不足(30-50nmol/L)和缺乏(<30nmol/L)状态三种状态。

经过排除标准筛选后,该研究还纳入了4209名参与者。那些维生素D缺乏的人更可能是吸烟者,服用抗高血压药物,并且与那些有足够维生素D的人相比,心血管疾病的水平更高。在单变量logistic回归中,与维生素D充足的受试者相比,那些维生素D缺乏(比值比为1.18; 95%CI为0.86-1.61; P=0.303)或不足(比值比为1.13; 95%CI为0.91; P=0.272)的患者不太可能有证据表明站立时发生血压稳定性受损。OH110也得到了相似结果:与维生素D充足的受试者相比,维生素D缺乏(比值比为0.85; 95%CI为0.52-1.40; P=0.528)或不足(比值比为0.86; 95%CI为0.61-1.21; P=0.384)。

总之,维生素D与老年人直立性低血压无显著相关性。 

原始出处:

Eamon J. Laird.et al.Vitamin D Status Is Not Associated With Orthostatic Hypotension in Older Adults.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13064

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    2019-07-23 phoebeyan520

    学习了

    0