Diabetes Care:低滴度GAD抗体的肥胖和2型糖尿病患者减肥手术后血糖控制良好

2020-12-14 MedSci原创 MedSci原创

当主要目的是缓解糖尿病时,T2D患者低滴度的GAD和保留C肽不应成为减肥手术的顾虑因素。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在通过评估肥胖和2型糖尿病(T2D)患者谷氨酸脱羧酶(GAD)抗体的有无来评估减肥手术后的糖尿病缓解情况。

研究人员针对221例接受肥胖症手术治疗的2型糖尿病和肥胖患者筛查了GAD水平。16例GAD患者中有9例,205例无GAD患者中的112例患者接受了手术治疗。通过GAD的有无来比较糖尿病的缓解和体重减轻效果。

GAD组的水平为16-91 IU/mL,伴有和没有GAD的患者在年龄、BMI、糖尿病病程、胰岛素、HbA1c和C肽治疗比例方面均相似(1354±548 vs. 1358±487 pmol/L)。术后1年和5年,两组患者的BMI降低和糖尿病缓解率相似(67% vs. 73%,P=0.71,56% vs. 57%,P=1.0)。

由此可见,当主要目的是缓解糖尿病时,T2D患者低滴度的GAD和保留C肽不应成为减肥手术的顾虑因素。
 
原始出处:
 
Ruveena Kaur,et al.Good Glycemic Outcomes Following Bariatric Surgery Among Patients With Type 2 Diabetes, Obesity, and Low-Titer GAD Antibodies.Diabetes care.2020.https://doi.org/10.2337/dc20-0804

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    2020-12-14 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2020-12-14 CHANGE

    什么时候有懒人用的减肥神药?

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