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Diabetologia：血糖和血脂危险因素在研究BMI对冠心病的影响中的作用？

2018-01-30 MedSci MedSci原创

糖尿病代谢综合征
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目前。关于血糖和血脂风险因素调节BMI对CHD影响尚不清楚。近日，国际杂志 《Diabetologia》上在线发表一项关于血糖和血脂危险因素在研究BMI对冠心病的影响中的作用的两步双样本孟德尔随机研究。在这项研究中，研究人员使用遗传证据调查了这些性状的影响。 研究人员使用了两种样品孟德尔随机确定：（1）BMI对CHD（60801病例 VS 123504对照组参与者），2型糖尿病（34840病

目前。关于血糖和血脂风险因素调节BMI对CHD影响尚不清楚。近日，国际杂志 《Diabetologia》上在线发表一项关于血糖和血脂危险因素在研究BMI对冠心病的影响中的作用的两步双样本孟德尔随机研究。在这项研究中，研究人员使用遗传证据调查了这些性状的影响。

研究人员使用了两种样品孟德尔随机确定：（1）BMI对CHD（60801病例 VS 123504对照组参与者），2型糖尿病（34840病例VS 114981对照组参与者），空腹血糖（n= 46186），胰岛素（n=38,238），HbA 1c（n=46,368）和LDL-胆固醇，HDL-胆固醇和三酰甘油（n=188,577）的因果效应。（2）血糖和血脂性状对CHD的影响；和（3）这些性状调节BMI对CHD的影响的程度。

研究发现更高的体重指数（〜4.5 kg/m 2）与较高冠心病危险性（OR 1.45 [95％CI 1.27,1.66]）和2型糖尿病（1.96 [95％CI 1.35,2.83]）,较高水平空腹血糖（0.07mmol / l [95％CI 0.03,0.1]），HbA 1c（0.05％[95％CI 0.01,0.08]），空腹胰岛素（0.18log pmol / l [95％CI 0.14,0.22]）和甘油三酯（0.20 SD [95％CI 0.14,0.26]）和较低水平的HDL-胆固醇（-0.23 SD [95％CI -0.32，-0.15]）相关。没有证据表明BMI与LDL-胆固醇之间存在因果关系。考虑不同水平pleiotropy模型进行敏感性分析后，高三酰甘油、HbA 1c、和糖尿病风险与CHD的因果关联仍然存在。三酰甘油或HbA 1c的遗传校正后，BMI-CHD效应分别从1.45降至1.16（95％CI 0.99,1.36）和1.36（95％CI 1.19,1.57），两个都校正后为1.09（95％CI 0.94,1.27 ）。

甘油三酯水平升高和血糖控制不佳似乎通过调节BMI对冠心病产生了一定的影响。

原始出处：

Lin Xu，Maria CarolinaBorges，Gibran Hemani, et al. The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study.

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    2019-01-11 ms9608593228839890

    #DIA#

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    2018-12-13 ms5439512287675881

    #BET#

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    2018-02-05 lou.minghong

    学习谢谢分享!

    0

  4. 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    2018-01-31 衣带渐宽

    学习

    0

  5. 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    2018-01-31 衣带渐宽

    学习

    0

  6. 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    2018-01-31 明月清辉

    谢谢分享.学习了

    0

  7. 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    2018-01-31 1dd8c52fm63(暂无匿称)

    了解了解.学习学习

    0

  8. 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    2018-01-31 榄枷檬

    谢谢分享

    0

  9. 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    2018-01-31 121832a9m88暂无昵称

    学习了

    0

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    2018-01-31 秀红

    学习了

    0

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