Diabetes Care:糖基化终末产物、氧化产物与2型糖尿病患者的心血管事件!

2017-12-06 xing.T MedSci原创

由此可见,较低水平的MetSO和高水平的选择性AGE与增加的CVD事件相关,这可能有助于解释2型糖尿病患者强化降糖治疗的效益有限的原因。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究旨在明确血浆中晚期糖基化终产物(AGE)和氧化产物(OP)是否可以预测2型糖尿病患者心血管疾病(CVD)的发生率。

在两个强化降糖研究中,测量了五种特定的AGE(甲基氢化咪唑酮、羧甲基赖氨酸、羧乙基赖氨酸、3-脱氧葡糖醛酮氢化咪唑酮和乙二醛氢咪唑酮)和两种OP(2-氨基己二酸和蛋氨酸亚砜[MetSO])基线水平,这两个强化降糖队列分别是:(1)退伍军人糖尿病试验(VADT)亚群(n=445)和(2)控制糖尿病患者心血管风险行动(ACCORD)研究的巢式病例对照亚组(n=271)。

研究人员发现增加的AGE和OP水平与年龄较大、肾功能下降、既往有CVD和糖尿病病程较长有关,但与血红蛋白无关。在VADT研究中,调整年龄、种族、性别、既往心血管疾病、肾功能、治疗分组以及糖尿病病程后,发生心血管事件的风险增加与较低的MetSO水平相关(n=107)(风险比[HR]为0.53;95%可信区间为0.28-0.99;P=0.047)。研究人员发现低浓度MetSO和高浓度3-脱氧葡萄糖醛酮氢化咪唑酮人群的CVD风险最高(HR为1.70;P=0.01)。在ACCORD研究中,那些发生心血管病事件的患者(n=136)具有较低的MetSO(14%;P=0.007)和较高的乙二醛氢化咪唑酮和羧甲基赖氨酸水平(分别为18%和15%,P=0.04);然而,对既往CVD事件进行调整后,只有MetSO仍具有显著性差异(P=0.002)。

由此可见,较低水平的MetSO和高水平的选择性AGE与增加的CVD事件相关,这可能有助于解释2型糖尿病患者强化降糖治疗的效益有限的原因。

原始出处:

Juraj Koska,et al. Advanced Glycation End Products, Oxidation Products, and Incident Cardiovascular Events in Patients With Type 2 Diabetes.Diabetes Care 2017. https://doi.org/10.2337/dc17-1740

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    2017-12-09 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

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    2017-12-08 lfyang
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