GUT:地中海饮食降低超重和肥胖受试者的血浆胆固醇并改善肠道微生物组成

2020-07-02 MedSci原创 MedSci原创

“地中海式饮食”是指有利于健康的,简单、清淡以及富含营养的饮食。本研究旨在探讨地中海饮食(MD)干预对具有代谢性疾病危险因素的受试者代谢,肠道微生物组和系统代谢组的影响。

背景及目的

“地中海式饮食”是指有利于健康的,简单、清淡以及富含营养的饮食。本研究旨在探讨地中海饮食(MD)干预对具有代谢性疾病危险因素的受试者代谢,肠道微生物组和系统代谢组的影响。

方法:

研究人员总共招募八十二名健康超重和肥胖的受试者,他们习惯性地摄入较少的水果和蔬菜,并且久坐不动,所有患者均参加了为期8周的平行随机对照试验。43名参与者消耗了根据其惯常能量摄入量(MedD)量身定制的MD,39名参与者保持了常规饮食(ConD)。

结果

MedD组中MD饮食成功地提高了受试者对纤维和动物蛋白的摄入量。血浆和尿液中肉碱水平的降低证实了有效性。与ConD组相比,MedD组的血浆胆固醇(主要结局)和粪便胆汁酸显着降低。MD干预导致降解纤维的Faecalibacterium prausnitzii的水平增加和与丁酸酯代谢有关的微生物碳水化合物降解基因的增加。MedD组的饮食变化导致尿中尿石素增加,粪便胆汁酸降解和胰岛素敏感性与特定微生物群有关。

结论

在保持能量摄入的情况下将受试者转为MD可以降低其血液胆固醇,并导致其微生物组和代谢组发生多种变化,这些变化与未来改善代谢健康的策略有关。

原始出处:

Victoria Meslier. Et al. Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake. GUT. 2020.

 

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    2020-07-05 健康达人

    地中海饮食是热点,被认为是最健康的饮食,而中国传统饮食一般被认为多半是不健康的,这是事实吗?其实需要更多严谨的科学证据,而不是猜测!

    0

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    2020-07-04 xinmeili
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    2020-07-04 wgx311
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    2020-07-02 站在塔尖

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