Clin Exp Allergy:季节性过敏性鼻炎患者下呼吸道中IL-33表达增加且与天然过敏原暴露无关

2021-02-09 AlexYang MedSci原创

在过敏性哮喘患者中,参与2型气道炎症发展的IL-33通路被激活。根据 "同一气道,同一疾病 "的概念,IL-33通路在过敏性鼻炎患者的气道中也应被激活。

在过敏性哮喘患者中,参与2型气道炎症发展的IL-33通路被激活。根据 "同一气道,同一疾病 "的概念,IL-33通路在过敏性鼻炎患者的气道中也应被激活

最近,有研究人员比较了季节性过敏性鼻炎患者(n=27)与季节性过敏性哮喘患者(n=23)、特应性无症状受试者(n=9)和健康对照组(n=17)在花粉季节内外测得痰液中IL-33及其mRNA前体的水平。研究发现,与对照组(0pg.ml-1;p<0.001)或特应性无症状受试者(0pg.ml-1;p=0.006)相比,过敏性鼻炎(9.4pg.ml-1)和哮喘患者(5.2pg.ml-1)的痰液上清液中IL-33水平中位数较高。qPCR也观察到同样的情况。过敏性鼻炎患者(4.9pg.ml-1 vs 7.1pg.ml-1,p=0.256)或过敏性哮喘患者(3.6pg.ml-1 vs 3.2pg.ml-1,p=0.61)的IL-33水平在花粉季节和非花粉季节相似。

最后,研究人员指出,IL-33在患有过敏性鼻炎的患者的下呼吸道中是可以检测到的,并且与过敏性哮喘患者的水平相似。这些水平似乎独立于过敏本身和过敏原暴露的自然变化。这些数据提供了无哮喘的过敏性鼻炎患者气道中上皮功能障碍的证据,进一步证实了将哮喘和鼻炎联系起来的 "同一个气道,同一种疾病 "的理论

原始出处:

Amaryllis Haccuria , Alain Van Muylem , Andreï Malinovschi et al. Increased expression of IL-33 is found in the lower airways of patients with seasonal allergic rhinitis and is not related to natural allergen exposure. Clin Exp Allergy. Jan 2021

 

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    2021-02-11 zhmscau
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    2021-02-11 膀胱癌
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    2021-02-11 宋威
  6. [GetPortalCommentsPageByObjectIdResponse(id=2047370, encodeId=eb36204e370e6, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Jul 01 15:30:01 CST 2021, time=2021-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1282555, encodeId=c5ac12825550f, content=<a href='/topic/show?id=700239e0772' target=_blank style='color:#2F92EE;'>#呼吸道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39707, encryptionId=700239e0772, topicName=呼吸道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e94174, createdName=zhmscau, createdTime=Thu Feb 11 01:30:01 CST 2021, time=2021-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329465, encodeId=6c391329465ad, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Thu Feb 11 01:30:01 CST 2021, time=2021-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442637, encodeId=fec2144263e9c, content=<a href='/topic/show?id=625194032a5' target=_blank style='color:#2F92EE;'>#过敏原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94032, encryptionId=625194032a5, topicName=过敏原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=81884942400, createdName=12498cb5m14暂无昵称, createdTime=Thu Feb 11 01:30:01 CST 2021, time=2021-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466249, encodeId=ff07146624914, content=<a href='/topic/show?id=9063966407' target=_blank style='color:#2F92EE;'>#IL-33#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9664, encryptionId=9063966407, topicName=IL-33)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=42dd6785219, createdName=宋威, createdTime=Thu Feb 11 01:30:01 CST 2021, time=2021-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468734, encodeId=47e91468e3428, content=<a href='/topic/show?id=a19b4540688' target=_blank style='color:#2F92EE;'>#季节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45406, encryptionId=a19b4540688, topicName=季节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cf986929326, createdName=30397606, createdTime=Thu Feb 11 01:30:01 CST 2021, time=2021-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533434, encodeId=757e15334344f, content=<a href='/topic/show?id=fe21454096b' target=_blank style='color:#2F92EE;'>#季节性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45409, encryptionId=fe21454096b, topicName=季节性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e4bd12435949, createdName=charleshjw, createdTime=Thu Feb 11 01:30:01 CST 2021, time=2021-02-11, status=1, ipAttribution=)]
    2021-02-11 30397606
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