Acta Biomater：新型水凝胶递送RNA干扰分子可有效治疗骨缺损

2018-06-22 MedSci MedSci原创

RNA干扰（RNAi）可能是促进功能组织生长的一种有效和有价值的工具，因为短干扰RNA（siRNA）和微小RNA（miRNA）可以阻断对组织再生具有负面影响的基因的表达。本课题组最近报道了由原位形成的聚乙二醇（PEG）水凝胶的针对头蛋白（siNoggin）和miRNA-20a的siRNA的局部和持续呈递增强了包裹的人骨髓间充质干细胞（hMSC）的成骨分化。本研究中，研究人员介绍了水凝胶体系在大鼠颅

RNA干扰（RNAi）可能是促进功能组织生长的一种有效和有价值的工具，因为短干扰RNA（siRNA）和微小RNA（miRNA）可以阻断对组织再生具有负面影响的基因的表达。本课题组最近报道了由原位形成的聚乙二醇（PEG）水凝胶的针对头蛋白（siNoggin）和miRNA-20a的siRNA的局部和持续呈递增强了包裹的人骨髓间充质干细胞（hMSC）的成骨分化。

本研究中，研究人员介绍了水凝胶体系在大鼠颅骨骨缺损模型中加速骨形成的能力。将水凝胶植入12周后，与含有不含siRNA的hMSCs或负对照siRNA的水凝胶相比，含有包裹hMSCs和miRNA-20a的水凝胶在骨缺损中可导致更多的骨形成。

该研究结果表明，这种局部和持续的RNA干扰分子递送系统可用于治疗骨及其他组织的缺损。

原始出处：

Nguyen MK, Jeon O, et al., RNA interfering molecule delivery from in situ forming biodegradable hydrogels for enhancement of bone formation in rat calvarial bone defects. Acta Biomater. 2018 Jun 7. pii: S1742-7061(18)30343-X. doi: 10.1016/j.actbio.2018.06.007.

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2018-09-18 1194695146_61857354

#RNA干扰#

40 0
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2018-08-31 windight

#CTA#

34 0
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2018-10-29 仁心济世

#Bio#

33 0
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2018-06-24 tastas

#水凝胶#

37 0
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2018-06-24 lfcmxl

#骨缺损#

24 0
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2018-06-24 lishizhe

#凝胶#

31 0
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2018-06-24 docwu2019

#有效治疗#

24 0
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2018-06-22 虈亣靌

好文.值得点赞!认真学习.应用于实践!谢谢分享给广大同好!

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