Dig Dis Sci:肥胖症会增加患有艰难梭菌感染的炎症性肠病患者结肠切除术风险

2019-06-10 不详 MedSci原创

肥胖和炎症性肠病(IBD)与艰难梭菌感染(CDI)的风险增加有关。因此,研究人员进行了这项研究,以检查肥胖对住院IBD患者CDI相关发病率和死亡率的影响。

背景
肥胖和炎症性肠病(IBD)与艰难梭菌感染(CDI)的风险增加有关。因此,研究人员进行了这项研究,以检查肥胖对住院IBD患者CDI相关发病率和死亡率的影响。

方法
研究人员通过临床数据库对2010年至2014年间确定患有CDI和IBD住院的≥18岁的患者进行了回顾性分析。比较了肥胖和非肥胖IBD-CDI患者的院内死亡率,部分或全部结肠切除术,住院时间和住院费用的结果。

结果
在304298例IBD住院患者中,13517例(4.4%)患者患有CDI。其中,996名(7.4%)患者为肥胖。肥胖IBD-CDI患者的结肠切除术风险较高(HR, 1.60,95%CI 1.30-1.96; p <0.001),住院时间较长(差异0.8天,95%CI 0.02-1.58; p = 0.04),与非肥胖IBD-CDI患者相比,住院费用较高(差异为11051美元,95%CI 1939-20,163; p = 0.02),但两组间死亡率无显着差异。

结论
患有CDI感染的IBD患者,肥胖会使结肠切除术风险增加60%,住院时间也会延长。

原始出处:

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