Eur Radiol: 小脑中脚的磁共振T1w/T2w比值可能是多系统萎缩的敏感生物指标！

2021-01-05 shaosai MedSci原创

目的：本研究使用髓磷脂敏感的MRI造影剂以及标准化的T1加权/ T2加权（sT1w / T2w）比值来检测多系统萎缩症小脑亚型（MSA-C）患者小脑中脚（MCP）的早期变化。

目的：本研究使用髓磷脂敏感的MRI造影剂以及标准化的T1加权/ T2加权（sT1w / T2w）比值来检测多系统萎缩症小脑亚型（MSA-C）患者小脑中脚（MCP）的早期变化。

方法：我们纳入了28名MSA-C患者，包括在发病2年内（早期MSA-C）的17名MSA-C患者和28名健康对照者。使用3-T MR系统获取T1w和T2w扫描。通过在标准化空间中勾画感兴趣区域的方法，使用SPM12分析了MCP中的sT1w / T2w比值。评价了MCP sT1w / T2w比值从匹配对照中区分MSA-C和早期MSA-C亚组的诊断性能。进行了相关性分析以评价MCP sT1w / T2w比值与其他临床参数之间的关系，其中包括量化小脑性共济失调的国际合作性共济失调量表（ICARS）评分。

结果：所有MSA-C患者（p <0.001）和17例早期（p <0.001）MSA-C患者的MCPsT1w / T2w比值均显着低于对照组。MCP sT1w / T2w比值在区分MSA-C与对照组上具有很高的灵敏度（96％）和特异性（100％）（曲线下面积= 0.99），即使在早期MSA-C组（曲线下面积= 0.99）亦是如此（灵敏度= 94％，特异性= 100％）。在早期MSA-C组中，MCP sT1w / T2w比值与ICARS评分有相关性。

结论：sT1w / T2w比值甚至可以在疾病早期就检测出MCP中MSA-C相关的变化，并且也许可以作为发现及诊断MSA-C的敏感的生物标志物。

原始出处：

Atsuhiko Sugiyama,Hajime Yokota,Shigeki Hirano,et al. Magnetic resonance T1w/T2w ratio in the middle cerebellar peduncle might be a sensitive biomarker for multiple system atrophy. PMID:33241514DOI:10.1007/s00330-020-07521-1

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2021-02-19 chendoc252

#萎缩#

36 0
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2021-01-07 1696533704_45270454

#磁共振#

31 0
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2021-01-07 珙桐

#多系统萎缩#

27 0
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2021-01-06 Houqiangcn

好好学习天天向上

91 0
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2021-01-05 ms5000000518166734

已读，受益匪浅

94 0
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2021-01-05 ms3000000710709215

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Eur Radiol: 小脑中脚的磁共振T1w/T2w比值可能是多系统萎缩的敏感生物指标！

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