卡西酮滥用的问题或许可通过疫苗解决

2018-04-23 MedSci MedSci原创

卡西酮(Cathinone)是一种在阿拉伯茶(khat)中发现的一元胺生物碱(monoaine alkaloid)。人工合成的卡西酮,能够模拟植物中发现的刺激作用,也经常被作为消遣性毒品的重要组成部分,在美国通常被叫做浴盐,这类药物的过量使用会引发危及生命的副作用,如器官衰竭等。

卡西酮(Cathinone)是一种在阿拉伯茶(khat)中发现的一元胺生物碱(monoaine alkaloid)。人工合成的卡西酮,能够模拟植物中发现的刺激作用,也经常被作为消遣性毒品的重要组成部分,在美国通常被叫做浴盐,这类药物的过量使用会引发危及生命的副作用,如器官衰竭等。

近日,研究人员为合成的卡西酮(浴盐)开发了疫苗。这种疫苗能够消除卡西酮对大脑的影响,这可能有助于经历复发的吸毒者的康复。

新疫苗靶对两种合成类卡西酮非常有效,它们分别为亚甲基二氧吡咯戊酮(MDPV)和α-吡咯烷酮戊二酮(α-PVP)。由于这些非法药物的化学结构经常被改变以规避药物法律,因此开发一种对多种合成卡西酮有效的疫苗是非常重要的。这项新研究的结果显示,接种疫苗的啮齿类动物产生了大量的抗体,这些抗体紧紧附着在血液中的MDPVα-PVP。这种免疫反应能够降低MDPV的兴奋效应。研究人员观察到接种大鼠与未处理的大鼠相比,MDPV诱导的运动显著减少,并显著缩短了MDPV诱导的活性。


原始出处:

https://www.europeanpharmaceuticalreview.com/news/75093/vaccine-cathinone-abuse/

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1701565, encodeId=3a811e0156545, content=<a href='/topic/show?id=bedc665998e' target=_blank style='color:#2F92EE;'>#滥用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66599, encryptionId=bedc665998e, topicName=滥用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea1030383785, createdName=zchen, createdTime=Fri May 04 22:37:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308816, encodeId=32c4308816c2, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Apr 24 10:05:39 CST 2018, time=2018-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308808, encodeId=511e308808ff, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Apr 24 09:45:38 CST 2018, time=2018-04-24, status=1, ipAttribution=)]
    2018-05-04 zchen
  2. [GetPortalCommentsPageByObjectIdResponse(id=1701565, encodeId=3a811e0156545, content=<a href='/topic/show?id=bedc665998e' target=_blank style='color:#2F92EE;'>#滥用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66599, encryptionId=bedc665998e, topicName=滥用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea1030383785, createdName=zchen, createdTime=Fri May 04 22:37:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308816, encodeId=32c4308816c2, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Apr 24 10:05:39 CST 2018, time=2018-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308808, encodeId=511e308808ff, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Apr 24 09:45:38 CST 2018, time=2018-04-24, status=1, ipAttribution=)]
    2018-04-24 明月清辉

    谢谢分享.学习了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1701565, encodeId=3a811e0156545, content=<a href='/topic/show?id=bedc665998e' target=_blank style='color:#2F92EE;'>#滥用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66599, encryptionId=bedc665998e, topicName=滥用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea1030383785, createdName=zchen, createdTime=Fri May 04 22:37:00 CST 2018, time=2018-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308816, encodeId=32c4308816c2, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Tue Apr 24 10:05:39 CST 2018, time=2018-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=308808, encodeId=511e308808ff, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Apr 24 09:45:38 CST 2018, time=2018-04-24, status=1, ipAttribution=)]
    2018-04-24 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0