空气污染是国人头号杀手"帮凶"!阜外医院顾东风院士团队BMJ文章称,长期PM2.5暴露增中风危险

2020-01-06 朱朱 文韬 中国循环杂志

12月30日,《英国医学杂志》刊登了阜外医院顾东风院士研究团队China-PAR研究的最新分析结果。该研究覆盖全国15个省市近12万居民,最长随访时间达23年。研究发现,长期暴露于PM2.5污染可明显增加国人中风危险,包括缺血性和出血性中风。研究者认为,该研究首次报道了我国PM2.5水平和中风危险增加的关系,为相关环境和健康政策的制定提供了依据。中风是我国国民第一位死亡病因。我国每12秒就有一人发

12月30日,《英国医学杂志》刊登了阜外医院顾东风院士研究团队China-PAR研究的最新分析结果。该研究覆盖全国15个省市近12万居民,最长随访时间达23年。

研究发现,长期暴露于PM2.5污染可明显增加国人中风危险,包括缺血性和出血性中风。

研究者认为,该研究首次报道了我国PM2.5水平和中风危险增加的关系,为相关环境和健康政策的制定提供了依据。

中风是我国国民第一位死亡病因。我国每12秒就有一人发生中风,每21秒就有一人死于中风。我国中风有高发病率、高致残率、高死亡率、高复发率、高经济负担五大特点。

研究发现,与PM2.5较低水平(<54.5 μg/m3)的居民相比,长期生活在PM2.5>78.2 μg/m3的居民,中风发病风险增加53%,缺血性和出血性中风的发病风险分别增加82%和50%。

进一步分析发现,PM2.5每升高10 μg/m3,中风、缺血性中风、出血性中风的发病风险分别增加13%、20%和12%。

研究人群PM2.5平均暴露水平为64.9 μg/m3。



大气PM2.5浓度与中风(上)、缺血性中风(中)、出血性中风(下)发生风险之间的关系

既往研究提示,PM2.5可引起血小板活化,促进凝血,从而导致血栓形成;长期暴露于PM2.5也可能通过增加血浆细胞因子的释放,引起炎症反应,加速动脉粥样硬化,进而增加缺血性中风发生风险。

而对于出血性中风,PM2.5长期暴露可能通过触发动脉血管收缩、引起血压升高和内皮功能障碍等增加脑血管破裂发生风险。

根据中国疾病负担研究报告,在导致我国居民疾病负担增加的危险因素中,空气颗粒物污染列第四位,仅次于高血压、吸烟和高钠饮食。

该研究团队利用国际先进的卫星遥感反演技术,评估得到了我国长时间(2000-2015年)、高空间分辨率(1×1 km)网格化大气PM2.5浓度。

中国医学科学院阜外医院实习研究员黄克勇、博士后梁凤超为该论文共同第一作者,顾东风院士为该论文的通讯作者。

来源:

1、Keyong Huang, et al. Long term exposure to ambient fine particulate matter and incidence of stroke: prospective cohort study from the China-PAR project. BMJ, 2019, 367: l6720.

2、王陇德,刘建民,杨弋,等. 我国脑卒中防治仍面临巨大挑战——《中国脑卒中防治报告2018》概要. 中国循环杂志, 2019, 34: 105-119.

3、殷鹏,齐金蕾,刘韫宁,等. 2005~2017年中国疾病负担研究报告. 中国循环杂志, 2019, 34: 1145-1154.

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    2020-01-31 wwzzly
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    2020-05-08 gaoxiaoe
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    2020-01-07 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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    2020-01-07 junJUN

    院士是学术至高点,也是大家必争之地呀

    0

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